SH2D2A and NAA16

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		SH2D2A	NAA16
Description		SH2 domain containing 2A	N-alpha-acetyltransferase 16, NatA auxiliary subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Transcription Regulator Complex Cytoplasm Cytosol NatA Complex Extracellular Exosome
	Molecular Function	Protein Binding SH3 Domain Binding	Protein Binding Acetyltransferase Activator Activity Acetyltransferase Activity Ribosome Binding
	Biological Process	Angiogenesis Signal Transduction Cell Differentiation T Cell Proliferation	N-terminal Protein Amino Acid Acetylation Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Protein Stabilization
Pathways		VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Sjögren's syndrome ( 28076899)	Keratoconus ( 33649486) Systolic blood pressure ( 30224653)
Interacting Genes		35 interacting genes: APPL1 AR ARID5A CRK DAPK1 EGFR ERBB2 ERBB3 ERBB4 GAB1 ITK KDR KIT LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MET MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1 ZYG11B	6 interacting genes: ENOX1 NAA10 NAA11 RPL26 SH2D2A SMURF1
Entrez ID		9047	79612
HPRD ID		05152	07977
Ensembl ID		ENSG00000027869	ENSG00000172766
Uniprot IDs		Q5UBZ2 Q5UBZ3 Q9NP31	A4FU51 Q6N069
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction ATP Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Nucleotide Binding Signal Transduction Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of MAPK Cascade Regulation Of Signaling Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Programmed Cell Death Transferase Activity Cellular Response To Growth Factor Stimulus Cellular Developmental Process Negative Regulation Of Programmed Cell Death Receptor Complex Cell Differentiation ERBB2 Signaling Pathway Protein Autophosphorylation Response To Growth Factor Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Protein Phosphorylation Regulation Of Epithelial Cell Proliferation Protein Phosphatase Binding Negative Regulation Of Defense Response SH2 Domain Binding Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Inflammatory Response Growth Factor Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Protein N-terminal-serine Acetyltransferase Activity NatA Complex Protein-N-terminal Amino-acid Acetyltransferase Activity N-terminal Protein Amino Acid Acetylation Protein Acetylation Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Regulation Of Translation Involved In Cellular Response To UV Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Engulfment Of Target By Autophagosome Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ultradian Rhythm Acyltransferase Activity Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Sister Chromatid Cohesion Activin Receptor Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Substrate Localization To Autophagosome Internal Protein Amino Acid Acetylation NADH Dehydrogenase Activity Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Maturation N-acetyltransferase Activity I-SMAD Binding Protein Targeting To Vacuole Involved In Autophagy Ectoderm Development Negative Regulation Of Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Binding
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