UBE2M and PINK1

Number of citations of the paper that reports this interaction (PubMedID 22388932)
51

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		UBE2M	PINK1
Description		ubiquitin conjugating enzyme E2 M	PTEN induced kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Presynapse Postsynapse Glutamatergic Synapse	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cytosol Cytoskeleton Membrane Axon Growth Cone Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity	Nucleotide Binding Magnesium Ion Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Peptidase Activator Activity Transferase Activity Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase B Binding Protein-containing Complex Binding Metal Ion Binding C3HC4-type RING Finger Domain Binding Protein Serine Kinase Activity
	Biological Process	Protein Modification By Small Protein Conjugation Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Postsynapse Assembly	Autophagy Of Mitochondrion Mitophagy Regulation Of Oxidative Phosphorylation Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Dopamine Secretion Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Protein Ubiquitination Respiratory Electron Transport Chain Hemopoiesis Positive Regulation Of Cell Migration Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Positive Regulation Of Catecholamine Secretion Cellular Response To Oxidative Stress Intracellular Signal Transduction TORC2 Signaling Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Catecholamine Secretion Protein Stabilization Establishment Of Localization In Cell Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Hypoxia Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Cellular Response To Toxic Substance Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Mitophagy Regulation Of Synaptic Vesicle Transport Negative Regulation Of Autophagosome Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Cristae Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Free Ubiquitin Chain Polymerization Cellular Response To Hydrogen Sulfide Positive Regulation Of Type 2 Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	PINK1-PRKN Mediated Mitophagy FOXO-mediated transcription of cell death genes
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Mean corpuscular hemoglobin ( 32888494)	Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		34 interacting genes: APP CAND1 CBL CFL1 CPNE1 CPNE2 CPNE4 CUL1 CUL2 CUL4A CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 NFKBIA PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3	23 interacting genes: APPL2 BAG2 BAG5 BCL2L1 CRLS1 DNM1L FBXO7 HSH2D MAP3K7 MARK2 NEAT1 PARK7 RNF31 SIAH1 SIAH3 SNCAIP SPATC1L TGM2 TOMM20 TOMM70 TRAF6 UBC UBE2M
Entrez ID		9040	65018
HPRD ID		04414	10514
Ensembl ID		ENSG00000130725	ENSG00000158828
Uniprot IDs		A0A024R4T4 P61081	Q9BXM7
PDB IDs		1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O	9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Protein Modification Process Protein Ubiquitination Cullin Family Protein Binding Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Post-translational Protein Modification Cullin-RING Ubiquitin Ligase Complex Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Protein Metabolic Process Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Protein Polyubiquitination Regulation Of Protein Neddylation Ubiquitin Ligase Complex Scaffold Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleus Cytosol Cytoplasm Establishment Of Protein Localization To Organelle Positive Regulation Of Metabolic Process Catabolic Process Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity Regulation Of Mitophagy Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Of Mitochondrion NEDD8 Transferase Activity Positive Regulation Of Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Proteasomal Protein Catabolic Process	Ubiquitin Protein Ligase Binding Mitochondrion Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Identical Protein Binding Mitochondrial Outer Membrane Regulation Of Inclusion Body Assembly Regulation Of Protein Stability Linear Polyubiquitin Binding Protein Targeting To Mitochondrion Regulation Of Programmed Cell Death Ubiquitin Conjugating Enzyme Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrion Organization Ubiquitin-protein Transferase Activity Mitochondrion Targeting Sequence Binding Protein Localization To Mitochondrion Positive Regulation Of Defense Response Interleukin-17A-mediated Signaling Pathway Regulation Of Protein Targeting To Mitochondrion Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway TOM Complex Negative Regulation Of Intracellular Signal Transduction Regulation Of Autophagy Of Mitochondrion Interleukin-33-mediated Signaling Pathway Regulation Of Apoptotic Process Mitochondrial Outer Membrane Translocase Complex Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Positive Regulation Of Catabolic Process CD40 Signaling Pathway Positive Regulation Of Autophagy TRIF-dependent Toll-like Receptor Signaling Pathway CD40 Receptor Complex Regulation Of Mitochondrial Membrane Potential Regulation Of Intracellular Signal Transduction Protein Metabolic Process Positive Regulation Of JUN Kinase Activity Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Establishment Of Protein Localization To Mitochondrion Protein Insertion Into Mitochondrial Outer Membrane Regulation Of Protein Localization Negative Regulation Of Protein Ubiquitination Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?