NAT8 and SMYD5

		NAT8	SMYD5
Description		N-acetyltransferase 8 (putative)	SMYD family member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Cytoplasm
	Molecular Function	L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups L-cysteine-S-conjugate N-acetyltransferase Activity Protein-lysine-acetyltransferase Activity	Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone H4K20 Methyltransferase Activity Metal Ion Binding Histone H4K20 Trimethyltransferase Activity Histone H3K36 Trimethyltransferase Activity
	Biological Process	Glutathione Metabolic Process Positive Regulation Of Gene Expression Peptidyl-lysine N6-acetylation Amyloid Fibril Formation	Cytoplasmic Translation Methylation Negative Regulation Of Gene Expression, Epigenetic Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Cytoplasmic Translational Elongation Regulation Of Stem Cell Division Regulation Of Stem Cell Differentiation
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 23535967) Glomerular filtration rate (creatinine) ( 28452372) Hemoglobin levels ( 32327693) Macrovascular complications in type 2 diabetes ( 33430853) Metabolic traits ( 21886157) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 33031748 24625756 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 26352407)
Interacting Genes		38 interacting genes: AQP6 ARL13B ATP6V0E1 BIK CD3E CD59 CD79A CERS4 CREB3L1 EBP FAM209A FFAR2 GOLT1A GPR152 HSD17B13 JPH1 LEPROTL1 LMNA MTIF3 NAT8B REEP2 SAR1A SLC10A6 SLC40A1 SLC71A2 SMAD4 SMYD5 SSB ST6GAL1 TGFBR1 TLCD4 TMEM143 TMEM14B TMEM31 TMX2 TRIM21 TSPAN31 YIPF4	7 interacting genes: H1-1 H2BC3 H3C1 H4C1 NAT8 ZNF417 ZNF587
Entrez ID		9027	10322
HPRD ID		08413	18080
Ensembl ID		ENSG00000144035	ENSG00000135632
Uniprot IDs		Q9UHE5	Q6GMV2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum	Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly DNA Binding Chromatin Remodeling Chromosome Chromatin Organization Protein Heterodimerization Activity Chromosome Organization L-cysteine-S-conjugate N-acetyltransferase Activity Protein-containing Complex Assembly Peptidyl-lysine N6-acetylation Telomere Organization Protein-containing Complex Organization Chromosome, Telomeric Region L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation N-acetyltransferase Activity CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation
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