WNT3A and FZD1

Number of citations of the paper that reports this interaction (PubMedID 10557084)
0

Data Source:
HPRD (in vivo)

		WNT3A	FZD1
Description		Wnt family member 3A	frizzled class receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Early Endosome Membrane Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Wnt-Frizzled-LRP5/6 Complex	Plasma Membrane Focal Adhesion Cell Surface Membrane Wnt Signalosome
	Molecular Function	Transcription Coactivator Activity Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Co-receptor Binding Identical Protein Binding Receptor Ligand Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity
	Biological Process	Osteoblast Differentiation In Utero Embryonic Development Somitogenesis Positive Regulation Of Cytokine Production Heart Looping Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Determination Of Left/right Symmetry Axonogenesis Axon Guidance Mesoderm Development Heart Development Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification COP9 Signalosome Assembly Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Hippocampus Development Cell Proliferation In Forebrain Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Dorsal/ventral Neural Tube Patterning Neurogenesis Hemopoiesis Platelet Activation Neuron Differentiation Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of B Cell Proliferation Midbrain Development Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Skeletal Muscle Cell Differentiation Post-anal Tail Morphogenesis Synaptic Vesicle Recycling B Cell Proliferation Inner Ear Morphogenesis Cell Fate Commitment Fat Cell Differentiation Myoblast Differentiation Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Somatic Stem Cell Division Positive Regulation Of Mesodermal Cell Fate Specification Paraxial Mesodermal Cell Fate Commitment Animal Organ Development Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Neurogenesis Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Organization Canonical Wnt Signaling Pathway Cardiac Muscle Cell Fate Commitment Positive Regulation Of Dermatome Development Secondary Palate Development Regulation Of Microtubule Cytoskeleton Organization Platelet Aggregation Cellular Response To Retinoic Acid Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel Presynapse Assembly Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation Regulation Of Postsynapse To Nucleus Signaling Pathway Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation Regulation Of RNA Biosynthetic Process	Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Xenobiotic Stimulus Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Autocrine Signaling Non-canonical Wnt Signaling Pathway Astrocyte-dopaminergic Neuron Signaling Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hard Palate Development Canonical Wnt Signaling Pathway Ventricular Septum Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Presynapse Assembly Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants Formation of paraxial mesoderm Formation of the posterior neural plate Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity	TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Alcohol-related hepatocellular carcinoma ( 34902334) Birth weight ( 31043758) Diastolic blood pressure ( 28135244) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401)	Blond vs. brown/black hair color ( 30531825) Dental caries ( 23259602) Pulse pressure ( 27841878) Schizophrenia ( 31735061) Systolic blood pressure ( 27841878)
Interacting Genes		11 interacting genes: DLG1 DLG2 DLG4 FZD1 GPC3 LRP1 LRP6 PORCN RYK WNT1 WNT2	6 interacting genes: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A
Entrez ID		89780	8321
HPRD ID		05897	04558
Ensembl ID		ENSG00000154342	ENSG00000157240
Uniprot IDs		P56704	Q9UP38
PDB IDs		7DRT 7URD 7URE 8TZR	8J9N 8J9O
Enriched GO Terms of Interacting Partners?		Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Wnt Signaling Pathway Wnt-protein Binding Central Nervous System Neuron Differentiation Cell-cell Signaling Signaling Cell Communication Wnt Signalosome Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Wnt Receptor Activity Cell Surface Receptor Signaling Pathway Anatomical Structure Morphogenesis Postsynaptic Density Membrane Ionotropic Glutamate Receptor Binding Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Cellular Component Organization Neuron Differentiation Branching Involved In Ureteric Bud Morphogenesis Glial Cell-neuron Signaling Tissue Morphogenesis Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway Cell Proliferation In Midbrain Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Signal Transduction Hard Palate Development GMP Kinase Activity Endocytic Vesicle Membrane Neuromuscular Junction Protein Localization To Cell Junction GDP Metabolic Process Juxtaparanode Region Of Axon Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tube Morphogenesis Protein Localization To Membrane Chemical Synaptic Transmission Kinase Binding Cellular Response To Potassium Ion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Low-density Lipoprotein Particle Receptor Activity Developmental Process Trans-synaptic Signaling Regulation Of BMP Signaling Pathway Neurogenesis	Midbrain Dopaminergic Neuron Differentiation Frizzled Binding Dopaminergic Neuron Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Cellular Response To Retinoic Acid Endocytic Vesicle Membrane Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Response To Retinoic Acid Receptor Ligand Activity Central Nervous System Neuron Differentiation Negative Regulation Of Axon Extension Positive Regulation Of Collateral Sprouting In Absence Of Injury Cell Fate Commitment Cytokine Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Chemotaxis Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Axonogenesis Wnt Signaling Pathway Cell Proliferation In Midbrain Regulation Of Developmental Growth Regulation Of Anatomical Structure Morphogenesis Regulation Of Axon Extension Regulation Of Animal Organ Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Projection Organization Neuron Differentiation Regulation Of Neurogenesis Negative Regulation Of Developmental Growth Golgi Lumen Signaling Receptor Binding System Development Mammary Gland Epithelium Development Positive Regulation Of Collateral Sprouting Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Neurogenesis Regulation Of Nervous System Development Juxtaparanode Region Of Axon Negative Regulation Of Neuron Projection Development Cellular Response To Lipid Wnt Signalosome Secondary Palate Development Presynapse Assembly Neuron Projection Development Cellular Response To Potassium Ion Negative Regulation Of Neurogenesis Regulation Of Neuron Projection Arborization Negative Regulation Of Nervous System Development Regulation Of Axonogenesis
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