AP3D1 and DUX4

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (pull down)

		AP3D1	DUX4
Description		adaptor related protein complex 3 subunit delta 1	double homeobox 4
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Endosome Membrane Membrane Membrane Coat AP-3 Adaptor Complex Axon Terminal Bouton Presynapse Postsynapse Presynaptic Endosome Glutamatergic Synapse Axon Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Nuclear Membrane
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Targeting Protein Targeting To Vacuole Intracellular Protein Transport Golgi To Vacuole Transport Lysosomal Transport Anterograde Axonal Transport Protein Transport Vesicle Organization Synaptic Vesicle Budding From Endosome Synaptic Vesicle Coating Vesicle-mediated Transport Antigen Processing And Presentation Melanosome Organization Protein Localization To Organelle Endosome To Melanosome Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Synaptic Vesicle Recycling Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Synaptic Vesicle Membrane Organization Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Protein Localization To Membrane Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Vesicle-mediated Transport In Synapse Zinc Ion Import Into Lysosome Melanosome Assembly	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition
Pathways			Zygotic genome activation (ZGA) Zygotic genome activation (ZGA)
Drugs
Diseases
GWAS		Height ( 28552196 31562340) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Monocyte count ( 32888494) Myocardial infarction ( 24916648) Pulse pressure ( 30578418) Red blood cell count ( 27863252 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: AP3S1 AP3S2 ARF1 ARF6 CCN2 CDC42 DUX4 FILNC1 GSK3A RUFY1 SLC30A3 VAMP7 VPS41	124 interacting genes: ACTG1 AP2A1 AP3D1 ARF1 ATP5F1C C1QBP CAND1 CAPN2 CAVIN1 CCT6A CLTC COPA CSE1L DDX21 DDX3X DDX5 DES DHX30 DHX36 DHX9 DYNC1H1 EEF2 EFTUD2 ENO1 EP300 EPRS1 FASN FLNA GAPDH GARS1 HMGB1 HNRNPA1L2 HNRNPF HNRNPH1 HNRNPK HNRNPM HNRNPU HSPD1 IARS1 IGF2BP1 IGF2BP3 ILF3 IQGAP1 LDHA MARS1 MCM7 MTHFD1 MYBBP1A MYH10 MYH9 MYL6B NCL NPM1 PABPC1 PABPC4 PARP1 PFAS PKM PPP2R1A PRKDC PRPF8 RAN RPL10 RPL10A RPL12 RPL13 RPL15 RPL17 RPL18 RPL19 RPL21 RPL22 RPL23 RPL23A RPL27A RPL3 RPL30 RPL31 RPL35 RPL36 RPL4 RPL6 RPL7 RPL7A RPL8 RPL9 RPN1 RPS10 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS2 RPS20 RPS24 RPS25 RPS3 RPS3A RPS4X RPS6 RPS7 RPS8 RPS9 SF3B1 SHMT2 SLC25A3 SLC25A5 SLC25A6 SNRNP200 SRSF3 TCP1 TUBB TUBB2A TUBB3 TUBB6 VDAC1 VDAC2 VIM XRCC5 XRCC6 YBX1
Entrez ID		8943	100288687
HPRD ID		06260
Ensembl ID		ENSG00000065000	ENSG00000260596
Uniprot IDs		A0A8V8TQW4 O14617	C3U3A0 Q9UBX2
PDB IDs		4AFI 9C58 9C59 9C5B 9C5C	5Z2S 5Z2T 5Z6Z 5ZFW 5ZFY 5ZFZ 6A8R 6DFY 6E8C 6U81 6U82
Enriched GO Terms of Interacting Partners?		Intracellular Transport AP-3 Adaptor Complex Vacuolar Transport Cellular Localization Establishment Of Localization In Cell Vesicle-mediated Transport Golgi Apparatus Golgi Vesicle Transport Vesicle Organization Membrane Organization Protein Transport Membrane Invagination Synaptic Vesicle Coating Intracellular Protein Localization Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Establishment Of Protein Localization Thioesterase Binding Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Organization Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Organelle Transport Along Microtubule Vesicle Fusion Regulation Of Transport Synaptic Vesicle Recycling Organelle Membrane Fusion Endosomal Vesicle Fusion Regulation Of Endocytosis Anterograde Synaptic Vesicle Transport Early Endosome Melanosome Assembly Golgi To Vacuole Transport Neuron Projection Regulation Of Actin Cytoskeleton Organization Lysosomal Transport Organelle Fusion Regulation Of Actin Filament-based Process Organelle Organization Platelet Dense Granule Organization Regulation Of Supramolecular Fiber Organization Intracellular Membrane-bounded Organelle Endosome Late Endosome Membrane Membrane Fusion Establishment Of Epithelial Cell Polarity Membrane Coat Phagocytosis, Engulfment Positive Regulation Of Transport Vesicle Cargo Loading Dendritic Spine Organization	RNA Binding Ribonucleoprotein Complex Cytosolic Ribosome Cytoplasmic Translation Structural Constituent Of Ribosome Ribosome Translation Cytosolic Large Ribosomal Subunit Focal Adhesion Cytosolic Small Ribosomal Subunit Macromolecule Biosynthetic Process Cytosol Extracellular Exosome Cytoplasm Nucleolus Ribonucleoprotein Complex Biogenesis Macromolecule Metabolic Process Small Ribosomal Subunit Nucleus Ribosomal Small Subunit Biogenesis Membrane Protein Metabolic Process Small-subunit Processome MRNA Binding Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA 5'-UTR Binding Nucleic Acid Metabolic Process Large Ribosomal Subunit RNA Processing Synapse Positive Regulation Of Cytoplasmic Translation Catalytic Step 2 Spliceosome Regulation Of Translation RRNA Metabolic Process RRNA Binding Post-transcriptional Regulation Of Gene Expression CRD-mediated MRNA Stabilization Positive Regulation Of Translation Double-stranded RNA Binding Regulation Of Cytoplasmic Translation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RRNA Processing Spliceosomal Complex Nucleic Acid Binding RNA Splicing Cadherin Binding Cellular Response To Cytokine Stimulus Nucleotide Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?