CDK5R2 and CAMK2A

Number of citations of the paper that reports this interaction (PubMedID 12223541)
61

Data Source:
HPRD (two hybrid, in vitro)

		CDK5R2	CAMK2A
Description		cyclin dependent kinase 5 regulatory subunit 2	calcium/calmodulin dependent protein kinase II alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cytoplasm Plasma Membrane Membrane Protein Kinase 5 Complex Growth Cone Neuron Projection Presynapse	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Dendrite Endocytic Vesicle Membrane Cell Projection Neuron Projection Dendritic Spine Synapse
	Molecular Function	Actin Binding Lipid Binding Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Migration Axon Guidance Brain Development Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Cytoskeleton Organization	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Interferon-beta Angiotensin-activated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Dendritic Spine Development Cellular Response To Type II Interferon Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Protein Localization To Plasma Membrane Peptidyl-threonine Autophosphorylation Regulation Of Endocannabinoid Signaling Pathway Regulation Of Neuron Migration
Pathways		NGF-stimulated transcription	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS		Male-pattern baldness ( 28196072) Obesity-related traits ( 23251661) QT interval ( 29213071) Refractive error ( 32231278)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Retinitis pigmentosa ( 33514863) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: ACTB ACTN1 CAMK2A CDK5 TUBA4A	90 interacting genes: ACTN1 ACTN2 ACTN4 ARID5A ATF1 ATP2A2 C1orf94 CACNA1B CAMK2N2 CDC37 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DAZAP2 DLG1 DSCAM EGFR ETS1 FAM168A FAM168B FXR1 GFAP GLB1L2 GRIA1 GRIN1 GRIN2A GRIN2B GRM5 HSF1 HYAL3 ITGA2B ITGB1BP1 ITPKA KRT18 KRT75 KRT76 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP22-1 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LENG8 LRRC7 MAPT MPDZ MRPL11 NDST1 NOS1 NTAQ1 PDC PPM1F PSMC5 PTTG1 RALYL RBFOX2 RBM47 RBPMS RBPMS2 RCHY1 RHOXF2 RIMS1 SMAD2 SOX5 SPMIP9 SQSTM1 SRF STAT1 SUOX SYNGAP1 TAB2 TANC1 TCAF1 TFAP2D TIAL1 TRIM55 TRIM63 TSR2 TTC5 VARS1 YWHAB ZBTB32
Entrez ID		8941	815
HPRD ID		04790	06532
Ensembl ID		ENSG00000171450	ENSG00000070808
Uniprot IDs		Q13319	A0A5F9ZH21 A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs			2VZ6 3SOA 5IG3 6OF8 6VZK 6W4O 6W4P 6X5G 6X5Q 7KL0 7KL1 7KL2 7REC 7UIQ 7UIR 7UIS 7UJP 7UJQ 7UJR 7UJS 7UJT 9EOY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Membrane Cell Junction Assembly Synapse Regulation Of Synaptic Vesicle Recycling Cytoskeleton Organization Organelle Organization Platelet Aggregation Tau Protein Binding Actin Cytoskeleton Organization Brush Border Actin Filament-based Process Homotypic Cell-cell Adhesion Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Cellular Localization Protein Localization To Cell Junction Actin Filament Cell Junction Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Peptidyl-threonine Autophosphorylation Regulation Of Neurotransmitter Secretion Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Structural Constituent Of Cytoskeleton Nucleotide Binding Regulation Of Norepinephrine Uptake Structural Constituent Of Postsynapse Acetylcholine Receptor Activator Activity Axonogenesis Transporter Regulator Activity Platelet Morphogenesis Regulation Of Endocannabinoid Signaling Pathway ErbB-2 Class Receptor Binding Protein Kinase 5 Complex Negative Regulation Of Synaptic Plasticity Cerebellar Cortex Formation Positive Regulation Of Transport Regulation Of Transepithelial Transport Cell Adhesion Lamellipodium Cell-cell Junction Regulation Of Protein Localization Protein Localization To Adherens Junction Dense Body Cell Junction Regulation Of Synaptic Plasticity Calcium- And Calmodulin-dependent Protein Kinase Complex	Intermediate Filament Regulation Of Synaptic Plasticity Dendritic Spine Modulation Of Chemical Synaptic Transmission Learning Or Memory Cognition Postsynaptic Density Glutamate-gated Calcium Ion Channel Activity Identical Protein Binding Neuron Projection Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Potential Associative Learning Positive Regulation Of Synaptic Transmission Synapse Postsynaptic Density Membrane Intracellular Signaling Cassette Learning Ligand-gated Ion Channel Signaling Pathway Regulation Of Membrane Potential Cytosol NMDA Glutamate Receptor Activity Cell Junction Organization Modulation Of Excitatory Postsynaptic Potential Transmembrane Transporter Binding Positive Regulation Of Macromolecule Biosynthetic Process Visual Learning Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Selective Glutamate Receptor Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Postsynaptic Actin Cytoskeleton Excitatory Chemical Synaptic Transmission Kinase Binding Visual Behavior Positive Regulation Of Biosynthetic Process Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Nucleobase-containing Compound Metabolic Process Synaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Kinase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Superior Olivary Nucleus Maturation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?