CCNC and HACE1

Number of citations of the paper that reports this interaction (PubMedID 35343092)
48

Data Source:
BioGRID (enzymatic study)

		CCNC	HACE1
Description		cyclin C	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Mediator Complex CKM Complex	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Membrane Nuclear Body Golgi Cisterna Membrane
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Identical Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Small GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II G0 To G1 Transition Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Protein Ubiquitination Rac Protein Signal Transduction Regulation Of Cell Migration Membrane Fusion Protein K48-linked Ubiquitination
Pathways		PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Daytime nap ( 33568662) Erectile dysfunction ( 30297428) Longevity (100 years and older) ( 33948810) Refractive error ( 32231278)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Age at voice drop ( 27182965) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Feeling guilty ( 29500382) Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Major depressive disorder ( 27479909) Menarche (age at onset) ( 27182965 19448622) Multiple sclerosis ( 23412934) Neuroblastoma ( 22941191) Obsessive-compulsive disorder ( 22889921) Resistant hypertension ( 31545351) Schizophrenia ( 28991256) Sporadic neuroblastoma ( 28545128) Thyroid stimulating hormone levels ( 17903292) Type 2 diabetes ( 31049640) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		79 interacting genes: ASH2L BLOC1S2 BTBD2 CCHCR1 CCNH CDK3 CDK8 CDKN2B CFAP53 CKS1B CRX DYDC1 ERCC3 ESR2 FAM161A FAM50B FAM90A1 FOXP2 FOXR2 GADD45GIP1 GLYR1 GOLGA2 GPC4 HACE1 HSPB1 ISY1 KRT13 KRT15 KRT16 KRT27 KRT31 KRT34 LCN2 LZTS2 MBD3 MBIP MCM2 MED8 MEOX2 MGST3 MYO15B NDUFB7 NEFL NMNAT1 NRBF2 PAX5 PLEKHO2 PLIN3 PNMA5 POU6F2 PRPF18 PUF60 RB1 RBM41 REL RFC5 RIBC1 RPA2 RUSC1 SERTAD3 SHC3 SPAG8 TADA3 TCEANC TEPSIN TEX12 TP63 TRAF3IP3 TRIM39 TRIM54 UBE2K VHL VTA1 ZFP90 ZNF18 ZNF426 ZNF620 ZNF688 ZNF792	10 interacting genes: CCNC MTDH OPTN PAK1 PLXNA2 RAB4A RAC1 SNTG2 UBE2D2 UBE2L3
Entrez ID		892	57531
HPRD ID		00456	17086
Ensembl ID		ENSG00000112237	ENSG00000085382
Uniprot IDs		E5RFK5 G5E954 P24863 Q7Z4L3	Q8IYU2
PDB IDs		3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP 5XQX 5XS2 6QTG 6QTJ 6R3S 6T41 6TPA 6Y0A 8TQ2 8TQC 8TQW 9H8C 9H8S	8H8X 8HAE 8PWL 8Q0N
Enriched GO Terms of Interacting Partners?		Nucleus Intermediate Filament Organization Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament DNA Binding Generation Of Catalytic Spliceosome For Second Transesterification Step Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Chromatin Cytoskeleton Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Structural Molecule Activity Axonemal A Tubule Inner Sheath Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Epithelial Cell Differentiation Epidermis Development Regulation Of Metabolic Process Importin-alpha Family Protein Binding Morphogenesis Of An Epithelium Regulation Of Mitotic Cell Cycle Phase Transition DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Phase Transition Anterograde Axonal Transport	Hepatocyte Growth Factor Receptor Signaling Pathway Recycling Endosome Membrane Regulation Of Fibroblast Migration Positive Regulation Of Microtubule Polymerization Semaphorin-plexin Signaling Pathway Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Protein Polymerization Regulation Of Microtubule Polymerization Positive Regulation Of Stress Fiber Assembly Actin Filament Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Actin Filament Bundle Assembly Cerebellar Granule Cell Precursor Tangential Migration G Protein Activity Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Nucleotide Binding Regulation Of Microtubule Polymerization Or Depolymerization Ruffle Membrane Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Regulation Of Stress Fiber Assembly Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis
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