BCL10 and CDC14B

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		BCL10	CDC14B
Description		BCL10 immune signaling adaptor	cell division cycle 14B
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GO Annotations	Cellular Component	Immunological Synapse Polkadots Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Membrane CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cell Junction Mitotic Spindle
	Molecular Function	Protease Binding Transcription Coactivator Activity Protein Binding Kinase Activator Activity Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Kinase B Binding Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding General Transcription Initiation Factor Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	B Cell Apoptotic Process Positive Regulation Of Cytokine Production Neural Tube Closure Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Apoptotic Process Cellular Defense Response Response To Fungus Programmed Cell Death Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Antifungal Innate Immune Response T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Microtubule Cytoskeleton Organization DNA Repair Protein Dephosphorylation DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Exit From Mitosis Positive Regulation Of Cytokinesis Cilium Assembly Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins	MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)	Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Intelligence (MTAG) ( 29326435) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		45 interacting genes: AKT1 ANP32B ATM BAAT CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NHERF1 NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1	21 interacting genes: BCL10 BUB1 CCND1 CDKN2A CHEK1 DLC1 MCC MFAP1 MLH3 MSH2 MTDH MYCBP2 PRKAB2 PSMB1 SIRT2 SKP2 SMAD4 SPANXN2 STK11 TP53 ZNF696
Entrez ID		8915	8555
HPRD ID		04625	04615
Ensembl ID		ENSG00000142867	ENSG00000081377
Uniprot IDs		A0A087WWW9 A2TDT2 O95999	A0A9L9PY50 O60729
PDB IDs		2MB9 6BZE 6GK2 8CZD 8CZO	1OHC 1OHD 1OHE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Modification Process CBM Complex Regulation Of Signal Transduction CARD Domain Binding Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of Signaling Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Pattern Recognition Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-2 Production Non-canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Innate Immune Response Positive Regulation Of Apoptotic Process	Nucleus Nucleoplasm Regulation Of Cell Cycle Phase Transition Replicative Senescence Mitotic DNA Integrity Checkpoint Signaling Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Response To X-ray Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition NF-kappaB Binding Regulation Of Cell Population Proliferation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Intracellular Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Post-translational Protein Modification Centromeric DNA Binding Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Response To UV Positive Regulation Of Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Growth Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Catabolic Process Positive Regulation Of Protein Modification Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mismatched DNA Binding Regulation Of Protein Ubiquitination P53 Binding Regulation Of Protein Modification Process MDM2/MDM4 Family Protein Binding General Transcription Initiation Factor Binding Centrosome Negative Regulation Of Growth Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cellular Component Organization Mitotic G1 DNA Damage Checkpoint Signaling Mammary Gland Epithelial Cell Proliferation
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