CCNA1 and RBL1

Number of citations of the paper that reports this interaction (PubMedID 10022926)
43

Data Source:
HPRD (in vivo, in vitro)

		CCNA1	RBL1
Description		cyclin A1	RB transcriptional corepressor like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Cyclin A2-CDK2 Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Promoter-specific Chromatin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Male Meiosis I Spermatogenesis Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Senescence
Pathways		G0 and Early G1 Telomere Extension By Telomerase Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Ub-specific processing proteases Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest G1/S-Specific Transcription Cyclin D associated events in G1
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010) Nickel levels ( 26025379)	Height ( 25429064) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 28957414 32888494)
Interacting Genes		40 interacting genes: ANAPC4 ARID2 BRCA1 BRCA2 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 FZR1 GPS2 H1-1 H1-5 H2BC1 INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 PSMA2 RACK1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC TRIM13 WEE1 XRCC6	55 interacting genes: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F1 E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A KMT5C LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB1 PLSCR1 PPP1R9B PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 TAF1 TOP1 TP53BP1 TSC22D2 USP4
Entrez ID		8900	5933
HPRD ID		04946	00312
Ensembl ID		ENSG00000133101	ENSG00000080839
Uniprot IDs		A0A140VJG0 P78396	P28749
PDB IDs			1H28 4YOO 4YOS 4YOZ 5TUV 7SMC 7SMD 7SME 7SMF
Enriched GO Terms of Interacting Partners?		Cyclin Binding Regulation Of Mitotic Cell Cycle Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of DNA Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Replication Nucleus Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Catalytic Activity Cell Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Regulation Of Kinase Activity Regulation Of Metabolic Process Chromosome, Telomeric Region Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Phosphorylation Regulation Of Lipid Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle DNA Damage Response Regulation Of Protein Modification Process Cellular Response To Stress Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle G2/M Phase Transition Positive Regulation Of DNA Metabolic Process	Nucleoplasm Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Cellular Response To Stress Mitotic Cell Cycle Phase Transition Response To Stress Cell Cycle Phase Transition Response To Growth Factor Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex DNA Binding
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