ACTN3 and DDAH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACTN3	DDAH2
Description		actinin alpha 3	DDAH family member 2, ADMA-independent
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Pseudopodium Cell Projection Extracellular Exosome	Cytoplasm Mitochondrion Extracellular Exosome
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding	Protein Binding Dimethylargininase Activity Hydrolase Activity
	Biological Process	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Actin Cytoskeleton Organization Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Development Bone Morphogenesis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Muscle System Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Relaxation Of Muscle Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate	Citrulline Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process
Pathways		Nephrin family interactions Striated Muscle Contraction
Drugs			Citrulline
Diseases
GWAS		Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Ulcerative colitis ( 28067908)
Interacting Genes		64 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BBS1 BRCA1 C1orf94 CADPS CATSPERT CIMAP1B CIMIP1 CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 DYNC1I2 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 XPO1 ZNF343 ZNF426	28 interacting genes: ACTN3 ANXA7 ATP1B1 CDC73 CDK4 CDKN1A DNAJB11 FANCL GADD45G IGFN1 MAP3K20 MKNK1 NOXA1 PIN1 PRKAB2 RAP1B RCC1 RPS6KA1 RPS6KA5 SCGN SMN1 STK3 TAF1D TK1 TNFSF11 TRIP13 TSC22D1 VAC14
Entrez ID		89	23564
HPRD ID		02148	09204
Ensembl ID		ENSG00000248746	ENSG00000213722
Uniprot IDs		A0A087WSZ2 B4DZQ2 Q08043	O95865 V9HW53
PDB IDs		1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?		Z Disc Pseudopodium Sarcomere Organization Actin Filament Binding Actin Binding Identical Protein Binding Cytoskeletal Protein Binding Actin Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Muscle Actinin Binding Muscle Alpha-actinin Binding Protein Binding Cardiac Muscle Thin Filament Assembly Actomyosin Structure Organization Actin Cytoskeleton I Band FATZ Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Telethonin Binding Stress Fiber Fascia Adherens Supramolecular Fiber Organization Muscle Cell Development Postsynaptic Actin Cytoskeleton Thioesterase Binding	Cytoplasm Nucleus Regulation Of Mitotic Cell Cycle Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Intracellular Signal Transduction Cytosol Regulation Of Cell Cycle Process Protein Kinase Activity JNK Cascade Response To Phorbol 13-acetate 12-myristate Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Positive Regulation Of Programmed Cell Death Epithelial Cell Proliferation Cellular Response To UV-B Protein Phosphorylation Identical Protein Binding Intracellular Signaling Cassette Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Phosphorylation Magnesium Ion Binding Regulation Of Programmed Cell Death Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Cycle Phase Transition Regulation Of Translation In Response To Stress Positive Regulation Of JNK Cascade Response To UV-B Regulation Of Cell Cycle Phase Transition Cellular Response To Gamma Radiation Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Cycle Process Regulation Of Multicellular Organismal Process Protein Binding Z Disc Phosphate-containing Compound Metabolic Process Signal Transduction Nucleotide Binding ATP Binding Cyclin Binding Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Nuclear Division Cis-trans Isomerase Activity Positive Regulation Of Apoptotic Process Histone H2AS1 Kinase Activity Positive Regulation Of Mitotic DNA Damage Checkpoint
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