CDC16 and TUBGCP3

		CDC16	TUBGCP3
Description		cell division cycle 16	tubulin gamma complex component 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Spindle	Spindle Pole Gamma-tubulin Complex Cytoplasm Centrosome Centriole Microtubule Organizing Center Spindle Polar Microtubule Cytosol Cytoskeleton Microtubule Membrane
	Molecular Function	Protein Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Gamma-tubulin Binding Microtubule Minus-end Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Nucleation Single Fertilization Cytoplasmic Microtubule Organization Spindle Assembly Meiotic Cell Cycle
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)	Glycated hemoglobin levels ( 20858683)
Interacting Genes		23 interacting genes: ANAPC10 ANAPC11 ANAPC7 BUB1B CDC20 CDC23 CDC27 CSTPP1 DAB2 DNAJA1 FTH1 HINT1 LINC00839 MAD2L1 MAPK9 MTNR1B PPP5C SKIL SMAD2 SMAD3 TUBGCP3 UBE2S XRCC5	12 interacting genes: AKAP9 ARTN CDC16 CEBPA DNAJB6 IMMT LRBA PCNT PROZ RASA3 TUBG1 TUBG2
Entrez ID		8881	10426
HPRD ID		04587	10289
Ensembl ID		ENSG00000130177	ENSG00000126216
Uniprot IDs		A0A3B3ISD2 B2RCW0 Q13042	A0A087WU06 B4DYP7 Q96CW5
PDB IDs		3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	6V6B 6V6S 6X0U 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 8Q62 8RX1 8VRD 8VRJ 8VRK
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Protein Branched Polyubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Sister Chromatid Separation Metaphase/anaphase Transition Of Cell Cycle Regulation Of Meiotic Cell Cycle Regulation Of Chromosome Segregation Regulation Of Chromosome Organization Regulation Of Chromosome Separation Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Positive Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Checkpoint Complex Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Positive Regulation Of Chromosome Separation Proteasomal Protein Catabolic Process Regulation Of Reproductive Process Regulation Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Nuclear Division Cytosol Protein Catabolic Process Regulation Of Organelle Organization Mitotic Cell Cycle Phase Transition Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Paraxial Mesoderm Morphogenesis Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Protein Ubiquitination Proteolysis Spindle Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Cycle Phase Transition	Microtubule Nucleation Microtubule Nucleator Activity Gamma-tubulin Ring Complex Gamma-tubulin Complex Mitotic Spindle Organization Centrosome Microtubule Cytoskeleton Organization Involved In Mitosis Meiotic Spindle Organization Pericentriolar Material Spindle Organization Microtubule Cytoskeleton Organization Mitotic Sister Chromatid Segregation Cytoskeleton Organization Sister Chromatid Segregation Spindle Microtubule Spindle Organelle Organization Nuclear Chromosome Segregation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cytoplasmic Microtubule Cytoplasmic Microtubule Organization Response To Vitamin B2 C/EBP Complex Microtubule CHOP-C/EBP Complex Microtubule Organizing Center Cytoskeleton Microtubule-based Process Peyer's Patch Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Dendritic Branch White Fat Cell Proliferation Glial Cell-derived Neurotrophic Factor Receptor Binding
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