SPHK1 and CTSB

Number of citations of the paper that reports this interaction (PubMedID 15710602)
0

Data Source:
HPRD (in vitro)

		SPHK1	CTSB
Description		sphingosine kinase 1	cathepsin B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Cilium Endosome Membrane Membrane Endocytic Vesicle Cytoplasmic Vesicle Early Endosome Membrane Intracellular Membrane-bounded Organelle Synapse Presynapse	Extracellular Region Extracellular Space Lysosome Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Endolysosome Lumen Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Peptidase Inhibitor Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Lipid Kinase Activity DNA Binding Protein Binding Calmodulin Binding ATP Binding Lipid Binding Sphingosine Kinase Activity Kinase Activity Acetyltransferase Activity Transferase Activity Sphingosine-1-phosphate Receptor Activity Protein Phosphatase 2A Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteoglycan Binding
	Biological Process	Blood Vessel Development Sphingosine-1-phosphate Receptor Signaling Pathway Protein Acetylation Lipid Metabolic Process Sphingosine Metabolic Process Inflammatory Response Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Calcium-mediated Signaling Regulation Of Endocytosis Sphingolipid Biosynthetic Process Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein Ubiquitination Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-17 Production Regulation Of Amide Metabolic Process Response To Tumor Necrosis Factor Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Contraction Sphingosine Biosynthetic Process Sphingoid Catabolic Process Regulation Of Lipid Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Phagocytosis Regulation Of Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Multicellular Organismal Process Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus DNA Biosynthetic Process Sphingolipid Mediated Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Microglial Cell Activation Regulation Of Endosomal Vesicle Fusion	Proteolysis Thyroid Hormone Generation Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Decidualization Symbiont Entry Into Host Cell Proteolysis Involved In Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Sphingolipid de novo biosynthesis Association of TriC/CCT with target proteins during biosynthesis VEGFR2 mediated cell proliferation Extra-nuclear estrogen signaling PKR-mediated signaling	Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation Degradation of CDH1
Drugs			2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucine N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases			Tropical calcific pancreatitis
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte count ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)	A body shape index ( 34021172) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Dental caries (decayed, missing and filled teeth) ( 31533690) Dilated cardiomyopathy (MTAG) ( 33495596) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Leprosy ( 27976721) Parkinson's disease ( 28892059 32201043) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Processed meat consumption ( 32066663) Refractive error ( 32231278) Triglyceride levels ( 29083408) Triglycerides ( 30275531) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		13 interacting genes: BIRC3 CTNND2 CTSB EP300 FYN KCTD17 LYN MBTPS1 RARG RPS6KC1 SPHKAP TRAF2 TRAF6	40 interacting genes: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD DSCR9 ERCC6 FAM118B HNRNPD HSPB2 IGF1 INS LCOR LINC00632 MARCKS MTDH PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 STK11 UBQLN4 XRN1
Entrez ID		8877	1508
HPRD ID		04768	00287
Ensembl ID		ENSG00000176170	ENSG00000164733
Uniprot IDs		Q53ZR5 Q9NYA1	A0A024R374 P07858
PDB IDs		3VZB 3VZC 3VZD 4L02 4V24	1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2 8B4T 8B5F 8HE9 8HEI 8HEN
Enriched GO Terms of Interacting Partners?		Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Modification Process Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of MAP Kinase Activity Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Regulation Of Apoptotic Process Immune Response-activating Cell Surface Receptor Signaling Pathway CD40 Receptor Complex Regulation Of Immune Response Regulation Of Programmed Cell Death Positive Regulation Of T Cell Activation Positive Regulation Of JUN Kinase Activity Leukocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway TORC2 Signaling Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Cell Activation Positive Regulation Of Intracellular Signal Transduction Response To Amino Acid Positive Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Protein Serine/threonine Kinase Activity Transferase Activity Signal Transduction Protein-containing Complex Binding Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Cell Projection Organization Positive Regulation Of Adaptive Immune Response Immune Response-activating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion	Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of Metabolic Process Extracellular Space Extracellular Matrix Negative Regulation Of Macromolecule Metabolic Process Extracellular Region Cysteine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Serine-type Endopeptidase Inhibitor Activity Regulation Of Phosphorus Metabolic Process Receptor Ligand Activity Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance AnxA2-p11 Complex Lipoprotein Particle Cellular Response To Amyloid-beta Insulin-like Growth Factor Receptor Binding Regulation Of Plasminogen Activation Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process Response To Amyloid-beta Positive Regulation Of Multicellular Organismal Process Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Protein Phosphorylation Endosome Lumen Insulin Receptor Binding Positive Regulation Of Glycolytic Process Response To UV-B Regulation Of Protein Catabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphorylation Regulation Of Metabolic Process Regulation Of ATP Metabolic Process Response To Alcohol Cellular Developmental Process Response To UV Extracellular Exosome Positive Regulation Of Plasma Membrane Repair Calcium-dependent Protein Binding
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