IL18R1 and CD48

Number of citations of the paper that reports this interaction (PubMedID 15760905)
0

Data Source:
HPRD (in vitro, in vivo)

		IL18R1	CD48
Description		interleukin 18 receptor 1	CD48 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Interleukin-18 Receptor Complex	Extracellular Region Plasma Membrane Membrane Membrane Raft Extracellular Exosome Side Of Membrane
	Molecular Function	Interleukin-1 Receptor Activity Protein Binding Hydrolase Activity Signaling Receptor Activity Interleukin-18 Binding Interleukin-18 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Protein Binding Receptor Ligand Activity
	Biological Process	Adaptive Immune Response Inflammatory Response Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Type II Interferon Production Interleukin-18-mediated Signaling Pathway T-helper 1 Cell Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Cytokine Production	Defense Response Immune Response Signal Transduction Natural Killer Cell Activation Leukocyte Activation
Pathways		Interleukin-37 signaling Interleukin-18 signaling	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) Asthma ( 29273806 31959851 22561531 31619474 31361310 20860503 30929738 26620591 23028483) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 29273806 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879 23042114) Atypical femoral fracture in phosphonate treatment ( 31006051) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576) Celiac disease ( 20190752 18311140) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 28067908) Delirium ( 29631748) Eczema ( 31361310) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Pediatric autoimmune diseases ( 26301688) Polymyositis ( 26362759) Primary biliary cholangitis ( 26394269) Sum eosinophil basophil counts ( 27863252)	Blood protein levels ( 30072576) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		6 interacting genes: AFF3 AKAP8L CD48 IL18 IL1RAP IL37	20 interacting genes: ACKR1 BRIX1 CD2 CD244 CD247 DIO1 E2F2 EEF1D EFNA1 EFNA3 FYN GNAI3 IL18R1 IL18RAP KPLCE LCK LY9 MAST2 OAZ3 P4HA1
Entrez ID		8809	962
HPRD ID		05138	00177
Ensembl ID		ENSG00000115604	ENSG00000117091
Uniprot IDs		B7ZKV7 Q13478	A0A087X1S7 P09326
PDB IDs		3WO3 3WO4 4R6U	2EDO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-13 Production Natural Killer Cell Activation Immune Response Cytokine-mediated Signaling Pathway Interleukin-18 Receptor Binding Defense Response Inflammatory Response Interleukin-33 Receptor Activity Receptor Ligand Activity Extracellular Region Immune System Process Regulation Of Cytokine Production Trans-synaptic Signaling By Trans-synaptic Complex Interleukin-1 Receptor Activity Interleukin-33-mediated Signaling Pathway Regulation Of Interleukin-6 Production Cytokine Activity Positive Regulation Of NK T Cell Proliferation Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of T-helper 2 Cell Differentiation Cellular Response To Lipopolysaccharide Sleep Positive Regulation Of T-helper 1 Cell Cytokine Production Super Elongation Complex DEAD/H-box RNA Helicase Binding Positive Regulation Of NK T Cell Activation T-helper 1 Type Immune Response Type 2 Immune Response Regulation Of MRNA Export From Nucleus Positive Regulation Of Interleukin-5 Production Positive Regulation Of Natural Killer Cell Proliferation Interleukin-1 Receptor Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Regulation Of Postsynaptic Density Assembly Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Interleukin-18-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Natural Killer Cell Proliferation Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Membrane Disassembly Nuclear Membrane Disassembly Lamin Binding Lymphocyte Activation Interleukin-1-mediated Signaling Pathway Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Positive Regulation Of Interleukin-4 Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Interleukin-5 Production	Leukocyte Activation Natural Killer Cell Activation Cell Activation Lymphocyte Activation T Cell Activation Adaptive Immune Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway CD8 Receptor Binding Signaling Receptor Activity Ephrin Receptor Signaling Pathway Fc Receptor Signaling Pathway CD4 Receptor Binding Plasma Membrane Phospholipase Activator Activity Positive Regulation Of Type II Interferon Production T Cell Receptor Binding Positive Regulation Of Immune System Process Interleukin-18-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Signal Transduction Phosphatidylinositol 3-kinase Binding Cell Surface Receptor Signaling Pathway Immune Response T Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Phospholipase Binding Regulation Of Type II Interferon Production Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Metabolic Process Antigen Receptor-mediated Signaling Pathway Immune System Process Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Immune Effector Process Signaling Receptor Binding Cellular Response To Glycine Response To Singlet Oxygen Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Interleukin-18 Positive Regulation Of Macromolecule Metabolic Process T Cell Costimulation Regulation Of Metabolic Process Regulation Of Immune System Process
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