IL18RAP and AFF3

		IL18RAP	AFF3
Description		interleukin 18 receptor accessory protein	ALF transcription elongation factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Interleukin-18 Receptor Complex	Nucleus Nucleoplasm Cytosol Nuclear Body Super Elongation Complex
	Molecular Function	Protein Binding Coreceptor Activity Hydrolase Activity Signaling Receptor Activity Interleukin-18 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity
	Biological Process	Adaptive Immune Response Immune System Process Inflammatory Response Immune Response Signal Transduction Cell Population Proliferation Interleukin-18-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-18	Regulation Of DNA-templated Transcription Regulation Of Gene Expression Response To Tumor Necrosis Factor Embryonic Hindlimb Morphogenesis
Pathways		Interleukin-18 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 23817571) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Celiac disease ( 20190752 22057235 18311140) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Extranodal natural killer T-cell lymphoma (nasal type) ( 31879220) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Systemic lupus erythematosus ( 28714469)	A body shape index ( 34021172) Adult body size ( 32376654) Age at first birth ( 27798627) Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 34103634) Autoimmune traits (pleiotropy) ( 30572963) Cannabis dependence symptom count ( 27028160) Celiac disease ( 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Extremely high intelligence ( 29520040) Gastroesophageal reflux disease ( 31527586 34187846) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31217584) Hip circumference adjusted for BMI ( 34021172) Household income ( 27818178) Household income (MTAG) ( 31844048) IgG levels ( 28628107) Immature fraction of reticulocytes ( 32888494) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Non-albumin protein levels ( 29403010) Number of children ever born ( 27798627) Plateletcrit ( 27863252 32888494) Red blood cell count ( 27863252) Refractive astigmatism ( 30306274) Regular attendance at a religious group ( 29970889) Rheumatoid arthritis ( 24390342 30572963 24782177 23143596 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Serum total protein levels ( 29403010) Triglyceride levels ( 34074324) Type 1 diabetes ( 25751624 34127860 17554260) Type 1 diabetes nephropathy ( 23028342) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: APP CD48 IL18 TRIM54
Entrez ID		8807	3899
HPRD ID		05147	03272
Ensembl ID		ENSG00000115607	ENSG00000144218
Uniprot IDs		O95256	P51826 Q8NAP7
PDB IDs		3WO4 6KN9 7FCH
Enriched GO Terms of Interacting Partners?		Receptor Ligand Activity Amyloid-beta Complex Immune Response Growth Cone Lamellipodium Positive Regulation Of Chemokine Production Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Positive Regulation Of Type II Interferon Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Leukocyte Activation Natural Killer Cell Activation Interleukin-18 Receptor Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Defense Response To Symbiont Defense Response To Other Organism Regulation Of Type II Interferon Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Gram-positive Bacterium Lipoprotein Particle Myeloid Leukocyte Activation Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Immune System Process Positive Regulation Of Inflammatory Response Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Membrane Raft Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission	Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Interleukin-18-mediated Signaling Pathway Cellular Response To Interleukin-18 Positive Regulation Of NF-kappaB Transcription Factor Activity Inflammatory Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Lymphocyte Mediated Immunity Interleukin-18 Binding Beta-galactoside Alpha-2,6-sialyltransferase Activity Response To Interleukin-18 Regulation Of DNA-binding Transcription Factor Activity Regulation Of Lymphocyte Mediated Immunity CARD8 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Immune Effector Process Signaling Receptor Activity Interleukin-1 Receptor Activity Positive Regulation Of T-helper 1 Cell Cytokine Production NLRP1 Inflammasome Complex Assembly Immune Response Adaptive Immune Response Sialylation Dipeptidyl-peptidase Activity Negative Regulation Of Bone Resorption Defense Response T-helper 1 Cell Differentiation Pyroptotic Cell Death Negative Regulation Of Bone Remodeling Sialyltransferase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of T-helper 1 Type Immune Response Regulation Of Immune System Process Hydrolase Activity Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of T Cell Cytokine Production Aminopeptidase Activity Negative Regulation Of Osteoclast Differentiation
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