TNFRSF11A and CBLB

Number of citations of the paper that reports this interaction (PubMedID 11406619)
0

Data Source:
HPRD (in vivo)

		TNFRSF11A	CBLB
Description		TNF receptor superfamily member 11a	Cbl proto-oncogene B
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GO Annotations	Cellular Component	Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Membrane Raft	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Raft Postsynapse Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity Receptor Tyrosine Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ossification Adaptive Immune Response Immune System Process Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Osteoclast Differentiation Response To Lipopolysaccharide Response To Insulin Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Zinc Ion Starvation Response To Tumor Necrosis Factor Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Ethanol Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of JNK Cascade Lymph Node Development Circadian Temperature Homeostasis Mammary Gland Alveolus Development Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Multinuclear Osteoclast Differentiation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Positive Regulation Of T Cell Anergy T Cell Anergy NLS-bearing Protein Import Into Nucleus Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Protein Ubiquitination Regulation Of Signaling Regulation Of Cell Adhesion Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Activation Positive Regulation Of Protein Catabolic Process T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Protein Catabolic Process At Postsynapse Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		ENMD-1198
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 30072576) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density ( 29499414 22504420) Myasthenia gravis ( 25643325) Paget's disease ( 20436471 21623375) Response to antipsychotic treatment ( 23241943) Serum albumin levels ( 23022100) Serum alkaline phosphatase levels ( 29403010 33339817 33547301) Vitiligo ( 27723757)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Antipsychotic drug-induced weight gain in schizophrenia or autism ( 31447353) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 20453840 28445677 31604244) Waist circumference ( 31647587) Zinc levels ( 26025379)
Interacting Genes		14 interacting genes: CBL CBLB ETFA FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6	54 interacting genes: APPL1 ARHGEF7 BLNK CD2AP CRKL CRY1 DAPK1 DUXAP9 EGFR FLT3 FYB1 FYN GLRX3 GORASP2 GRAP2 GRB2 HNRNPK IFT57 KIT LRRK1 LRRK2 MFHAS1 NCK1 NCK2 NEDD4 NEDD8 OSTF1 PIK3R1 PLCG2 PRMT2 PTK6 RET RNF11 SH3KBP1 SH3RF1 SHC1 SORBS2 SORBS3 SP7 SPRY2 SYK TGFB1I1 TNFRSF11A UBASH3A UBASH3B UBC UBE2D2 UBE2L3 VAV1 VAV2 VAV3 VPS26C YES1 ZAP70
Entrez ID		8792	868
HPRD ID		04609	05136
Ensembl ID		ENSG00000141655	ENSG00000114423
Uniprot IDs		Q9Y6Q6	B3KSS7 B4DYP3 B7ZAG1 Q13191
PDB IDs		1LB5	2AK5 2BZ8 2DO6 2J6F 2JNH 2LDR 2OOA 2OOB 3PFV 3VGO 3ZNI 8GCY 8QNG 8QNH 8QNI 8QTG 8QTH 8QTJ 8QTK 8VW4 8VW5 9FQH 9FQI 9FQJ
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Thioesterase Binding CD40 Receptor Complex Signaling Adaptor Activity Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Toll-like Receptor 3 Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Membrane Raft Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Bone Resorption Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Cytoplasmic Side Of Plasma Membrane Positive Regulation Of T Cell Cytokine Production Positive Regulation Of DNA-binding Transcription Factor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Serine/threonine Kinase Activity Ubiquitin Protein Ligase Binding	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Cell Motility Positive Regulation Of Cell Communication Cytoplasm Positive Regulation Of Signaling Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Intracellular Signaling Cassette Cell Activation Fc Receptor Mediated Stimulatory Signaling Pathway Leukocyte Migration Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Lymphocyte Activation Lamellipodium Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lamellipodium Organization Regulation Of Cell Activation Fc-epsilon Receptor Signaling Pathway Leukocyte Activation Immune System Process Cytosol T Cell Activation Positive Regulation Of Cell Activation
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