RNMT and PLEKHA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNMT	PLEKHA3
Description		RNA guanine-7 methyltransferase	pleckstrin homology domain containing A3
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm MRNA Capping Enzyme Complex Receptor Complex MRNA Cap Methyltransferase RNMT:RAMAC Complex	Golgi Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane Recycling Endosome
	Molecular Function	RNA Binding MRNA 5'-cap (guanine-N7-)-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity	Protein Binding Lipid Binding Identical Protein Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	7-methylguanosine MRNA Capping MRNA Processing Methylation RNA 5'-cap (guanine-N7)-methylation Cellular Response To Leukemia Inhibitory Factor	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi
Pathways		RNA Pol II CTD phosphorylation and interaction with CE during HIV infection mRNA Capping RNA Pol II CTD phosphorylation and interaction with CE	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Fractures ( 30158200)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: EIF4E GMCL1 KPNA2 PLEKHA3 RNGTT	9 interacting genes: DOK3 ERRFI1 MORF4L1 MRPL45 MYO15B PRKRA RNMT SH2B2 TCL1B
Entrez ID		8731	65977
HPRD ID		04622	09688
Ensembl ID		ENSG00000101654	ENSG00000116095
Uniprot IDs		A8K946 K7EP06 O43148	Q9HB20
PDB IDs		3BGV 3EPP 5E8J 5E9J 5E9W 8Q69 8Q8G 8Q9W	2KCJ 2MDX 3RCP
Enriched GO Terms of Interacting Partners?		Eukaryotic Initiation Factor 4G Binding MRNA Guanylyltransferase Activity MRNA 5'-triphosphate Monophosphatase Activity Inorganic Triphosphate Phosphatase Activity RNA Guanylyltransferase Activity Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Polynucleotide 5'-phosphatase Activity MRNA Cap Binding Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse Viral Penetration Into Host Nucleus Nuclear Transport Nucleocytoplasmic Transport Intracellular Transport Of Virus 7-methylguanosine MRNA Capping Host Cell Intracellular Transport NLS-dependent Protein Nuclear Import Complex RNA Cap Binding RNA 7-methylguanosine Cap Binding Chromatoid Body Eukaryotic Translation Initiation Factor 4F Complex
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