TNFRSF25 and EIF2S2

		TNFRSF25	EIF2S2
Description		TNF receptor superfamily member 25	eukaryotic translation initiation factor 2 subunit beta
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GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex Synapse
	Molecular Function	Tumor Necrosis Factor Receptor Activity Signaling Receptor Activity	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Zinc Ion Binding Translation Initiation Factor Binding Metal Ion Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Male Germ Cell Proliferation Cytoplasmic Translational Initiation Translation Translational Initiation Male Gonad Development
Pathways		TNFs bind their physiological receptors	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress
Drugs
Diseases
GWAS			Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Refractive error ( 32231278) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)
Interacting Genes		13 interacting genes: BAG4 DAP3 DYRK1A EIF2S2 MAPK1 NCOA7 NPPB SLC2A5 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2	28 interacting genes: AAR2 APLP1 APP CCDC90B CEBPA CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 KIZ NCK1 OGT PLEKHM1 PRKDC TLE1 TNFRSF25 TP53 UNC119 ZBTB16
Entrez ID		8718	8894
HPRD ID		04532	04882
Ensembl ID		ENSG00000215788	ENSG00000125977
Uniprot IDs		Q93038	P20042 Q6IBR8
PDB IDs		5YGP 5YGS	6K71 6K72 6YBV 6ZMW 6ZP4 7A09 7D43 7QP6 8OZ0 8PJ1 8PPL
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Superfamily Complex Non-canonical NF-kappaB Signal Transduction Tumor Necrosis Factor Receptor Binding Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Programmed Cell Death Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Tumor Necrosis Factor Negative Regulation Of MRNA Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Response To Tumor Necrosis Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Intracellular Signaling Cassette Regulation Of Apoptotic Process Receptor Complex Regulation Of Programmed Cell Death Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Histone H3T45 Kinase Activity Diuretic Hormone Activity Positive Regulation Of Protein Phosphorylation Response To Epidermal Growth Factor Fructose Import Across Plasma Membrane Positive Regulation Of Signal Transduction TORC2 Complex Disassembly Negative Regulation Of MRNA Modification Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Cytosine Metabolic Process TRAF2-GSTP1 Complex TORC1 Complex Assembly	Translation Initiation Factor Activity Regulation Of Translation Eukaryotic Translation Initiation Factor 2B Complex Translational Initiation Regulation Of Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Glial Cell Development Translation Oligodendrocyte Development Central Nervous System Development Cytoplasmic Translational Initiation Response To Heat T Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Response To Glucose Signal Transduction Transcription Regulator Complex Cytosol Response To Monosaccharide Cell Surface Receptor Signaling Pathway Response To Hormone Response To Temperature Stimulus Antigen Receptor-mediated Signaling Pathway Response To Carbohydrate Protein-containing Complex Organization Cell Development Regulation Of Apoptotic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Eukaryotic Initiation Factor EIF2 Binding Macromolecule Biosynthetic Process Response To Peptide Hormone Molecular Function Activator Activity Cell Death Cellular Response To Norepinephrine Stimulus Macromolecule Metabolic Process Response To Norepinephrine Protein-containing Complex Assembly Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Programmed Cell Death Regulation Of Proteolysis Protein Domain Specific Binding PML Body Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process B Cell Lineage Commitment
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