VAMP4 and TMEM205

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VAMP4	TMEM205
Description		vesicle associated membrane protein 4	transmembrane protein 205
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Transport Vesicle Endocytic Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane SNARE Complex Trans-Golgi Network Membrane Phagocytic Vesicle Bounding Membrane Of Organelle Presynaptic Endosome Membrane Glutamatergic Synapse	Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Synaptic Vesicle To Endosome Fusion Vesicle-mediated Transport Endocytic Recycling SNARE Complex Assembly Regulation Of Golgi To Plasma Membrane Protein Transport Golgi To Plasma Membrane Protein Transport Cellular Response To Type II Interferon Golgi Ribbon Formation Vesicle-mediated Transport To The Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Regulation Of Synaptic Vesicle Endocytosis
Pathways		Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 25625606) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		51 interacting genes: ANKS6 AP1M1 AQP6 ARL13B BCL2L13 BIK CD79A CFTR CISD2 CPLX4 CSNK2A1 CYB5R3 CYP1A1 DNAJC5 EBP ELOVL4 ERGIC3 EVI2B FAM209A FAM210B GPR152 GPX8 HSD17B13 KASH5 LDLRAD1 LEUTX MFF MGST3 MTIF3 PACS1 PSCA PTGES REEP4 RETREG3 SAR1A SCN3B SEC11C SLC10A6 SLC35H1 SSMEM1 STOM STX16 STX1A STX4 STX6 SYT2 TM4SF19 TMEM205 TMEM51 TMX2 TRIM54	16 interacting genes: ARL6IP6 BNIP3 COMT FXYD6-FXYD2 GOSR2 NDUFA3 PLN SMAGP STX6 STX7 STX8 TMEM11 TMEM140 TREX1 VAMP4 VRK2
Entrez ID		8674	374882
HPRD ID		06070	18605
Ensembl ID		ENSG00000117533	ENSG00000105518
Uniprot IDs		O75379 Q6IAZ3	Q6UW68
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane SNARE Binding SNARE Complex Vesicle Docking Endoplasmic Reticulum Membrane Organelle Localization By Membrane Tethering Endoplasmic Reticulum SNAP Receptor Activity Membrane Docking Glutathione Peroxidase Activity Synaptic Vesicle Membrane Protein Binding Steroid Biosynthetic Process Synaptic Vesicle Exocytosis Cholesterol Biosynthetic Process Chloride Channel Inhibitor Activity Unsaturated Fatty Acid Metabolic Process ATP-dependent Protein Binding Mitochondrial Membrane Vesicle Fusion Chromaffin Granule Membrane Sterol Biosynthetic Process Organelle Membrane Fusion Small Molecule Biosynthetic Process Vesicle Organization Mitochondrial Outer Membrane Syntaxin Binding Vesicle-mediated Transport SNARE Complex Assembly Organelle Fusion Intracellular Protein Transport Endomembrane System Membrane Fusion	SNARE Complex SNAP Receptor Activity Organelle Fusion Vesicle Organization SNARE Binding Vesicle Vesicle Fusion Organelle Membrane Fusion Synaptic Vesicle To Endosome Fusion Membrane Membrane Fusion Syntaxin Binding Membrane Organization Chloride Channel Inhibitor Activity Vesicle Docking Organelle Localization By Membrane Tethering Phagocytic Vesicle Membrane Docking Establishment Of Protein Localization Endomembrane System Regulation Of Protein Localization To Plasma Membrane Recycling Endosome Protein Transport Response To Oxidative Stress Regulation Of Protein Localization To Cell Periphery Vesicle-mediated Transport Regulation Of Protein Localization To Membrane Mitochondrial Membrane Trans-Golgi Network Cellular Response To Oxidative Stress Mitochondrion Autophagosome Adaptor Activity Norepinephrine Secretion Catechol O-methyltransferase Activity Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Organelle Envelope Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Organelle Organization Nuclear Envelope Visual Learning Regulation Of Cellular Localization Intracellular Protein Transport Endoplasmic Reticulum Cellular Response To Chemical Stress Establishment Of Localization In Cell Cellular Response To Phosphate Starvation Visual Behavior
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