EIF3J and METTL3

Number of citations of the paper that reports this interaction (PubMedID 30232453)
28

Data Source:
BioGRID (pull down)

		EIF3J	METTL3
Description		eukaryotic translation initiation factor 3 subunit J	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex Oxidoreductase Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding Identical Protein Binding	MRNA M(6)A Methyltransferase Activity RNA Binding MRNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity Transferase Activity Protein Heterodimerization Activity S-adenosyl-L-methionine Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation	MRNA Splicing, Via Spliceosome RNA Methylation Immune System Process MRNA Processing MRNA Export From Nucleus DNA Damage Response Spermatogenesis Circadian Rhythm Dosage Compensation By Inactivation Of X Chromosome MRNA Modification Stem Cell Population Maintenance Forebrain Radial Glial Cell Differentiation Cell Differentiation Primary MiRNA Processing Methylation Cellular Response To UV Gliogenesis Innate Immune Response Regulation Of T Cell Differentiation Positive Regulation Of Translation Negative Regulation Of Notch Signaling Pathway Oogenesis Rhythmic Process Regulation Of Meiotic Cell Cycle Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Endothelial To Hematopoietic Transition Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Cap-independent Translational Initiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Anti-Toxoplasma gondii IgG seropositivity ( 30610941)	Response to Homoharringtonine (cytotoxicity) ( 25628645)
Interacting Genes		16 interacting genes: ABCE1 CASP3 CSNK2A1 EIF3A EIF3B EIF3C EIF3D EIF3K GNB5 GOLM1 MAGED1 METTL3 NFE2L2 SIAH1 TADA3 TPD52L1	9 interacting genes: EIF3G EIF3I EIF3J EIF3M MAPK1 MAPK14 MAPK8 MTDH USP5
Entrez ID		8669	56339
HPRD ID		04883	14389
Ensembl ID		ENSG00000104131	ENSG00000165819
Uniprot IDs		O75822	Q86U44
PDB IDs		2KRB 3BPJ 6YBW 6ZMW 6ZVJ	5IL0 5IL1 5IL2 5K7M 5K7U 5K7W 5L6D 5L6E 5TEY 5YZ9 6TTP 6TTT 6TTV 6TTW 6TTX 6TU1 6Y4G 7ACD 7NHG 7NHH 7NHI 7NHJ 7NHV 7NI7 7NI8 7NI9 7NIA 7NID 7O08 7O09 7O0L 7O0M 7O0P 7O0Q 7O0R 7O27 7O28 7O29 7O2E 7O2F 7O2H 7O2I 7O2X 7OED 7OEE 7OEF 7OEG 7OEH 7OEI 7OEJ 7OEK 7OEL 7OEM 7OQL 7OQO 7OQP 7RX6 7RX7 7RX8 8BN8 8PW8 8PW9 8PWA 8PWB 9G4S 9G4U 9G4W
Enriched GO Terms of Interacting Partners?		Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translational Initiation Cytoplasmic Translational Initiation Translation Initiation Factor Activity Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m IRES-dependent Viral Translational Initiation Translation Protein-RNA Complex Assembly Regulation Of Translation Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Cytosol Rhythmic Process Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Primary Metabolic Process Macromolecule Biosynthetic Process Protein Catabolic Process Translation Initiation Factor Binding Execution Phase Of Apoptosis Regulation Of Protein Stability Positive Regulation Of Apoptotic Signaling Pathway Viral Process Positive Regulation Of Amide Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Macromolecule Metabolic Process Positive Regulation Of Glutathione Biosynthetic Process Negative Regulation Of Endoribonuclease Activity GTPase Activator Complex G-protein Gamma-subunit Binding Cytoplasm Protein-containing Complex Organization Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Phospholipase A2 Activator Activity Regulation Of Glutathione Biosynthetic Process Aflatoxin Catabolic Process Endoribonuclease Inhibitor Activity Regulation Of Endoribonuclease Activity RNA Binding	Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Cytoplasmic Translational Initiation Translation Initiation Factor Activity MAP Kinase Activity Translational Initiation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Lipopolysaccharide-mediated Signaling Pathway Protein-RNA Complex Assembly Protein Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Protein-containing Complex Assembly Protein-containing Complex Organization Translation Positive Regulation Of Cyclase Activity Peptidyl-threonine Phosphorylation Canonical Inflammasome Complex Assembly MAPK Cascade Macromolecule Metabolic Process Cytoplasm Macromolecule Biosynthetic Process Cellular Component Assembly Response To Lipopolysaccharide Cellular Senescence Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation JUN Phosphorylation Response To Molecule Of Bacterial Origin Cytosol Energy Homeostasis Protein Serine Kinase Activity Regulation Of Immune Response Protein Serine/threonine Kinase Activity Protein Phosphatase Binding Cytosine Metabolic Process Cellular Response To Tumor Necrosis Factor Regulation Of Synaptic Membrane Adhesion Interleukin-34-mediated Signaling Pathway JUN Kinase Activity Regulation Protein Catabolic Process At Presynapse Regulation Of Ossification Response To Nutrient Levels Ficolin-1-rich Granule Lumen Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Protein Kinase Activity Regulation Of Golgi Inheritance
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