EIF3A and RNF139

Number of citations of the paper that reports this interaction (PubMedID 20068067)
54

Data Source:
BioGRID (pull down)

		EIF3A	RNF139
Description		eukaryotic translation initiation factor 3 subunit A	ring finger protein 139
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Microtubule Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex Protein-containing Complex Eukaryotic 48S Preinitiation Complex Organelle Multi-eIF Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Receptor Tyrosine Kinase Binding	Protease Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Signaling Receptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Reinitiation Translation Translational Initiation Negative Regulation Of ERK1 And ERK2 Cascade IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation	Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Negative Regulation Of Translation Protein Destabilization ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Processing Endoplasmic Reticulum Mannose Trimming Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Keratoconus ( 33649486) Plateletcrit ( 32888494)
Interacting Genes		26 interacting genes: BBS1 BBS4 BZW2 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FXR1 LAMTOR5 LINC01554 MTNR1B PAIP1 REL RNF10 RNF139 SRPK2 TFIP11 TSC1 UBC UPF1 WEE2-AS1 YWHAZ	8 interacting genes: CDK4 CFTR COPS5 EIF3A UBE2H UBE2U UBE2Z VHL
Entrez ID		8661	11236
HPRD ID		03618	04333
Ensembl ID		ENSG00000107581	ENSG00000170881
Uniprot IDs		Q14152	Q8WU17
PDB IDs		3J8B 3J8C 6YBD 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Regulation Of Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Regulation Of Translational Initiation Eukaryotic 43S Preinitiation Complex Protein-RNA Complex Assembly Post-transcriptional Regulation Of Gene Expression RNA Binding Translation Eukaryotic Translation Initiation Factor 4F Complex RNA Strand Annealing Activity Viral Translational Termination-reinitiation BBSome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cytosol TORC1 Signaling Protein-containing Complex Organization Hippocampus Development Cytoplasm Striatum Development Negative Regulation Of Catabolic Process Regulation Of Cilium Beat Frequency Cerebral Cortex Development Regulation Of Protein Metabolic Process TOR Signaling Retina Homeostasis Protein-containing Complex Assembly Cytoplasmic Stress Granule Regulation Of Circadian Sleep/wake Cycle, Sleep Cellular Component Assembly Ventricular System Development Brain Morphogenesis Translation Factor Activity, RNA Binding Regulation Of TORC1 Signaling Translation Initiation Factor Binding Protein Metabolic Process Negative Regulation Of Autophagy Regulation Of Circadian Sleep/wake Cycle Regulation Of Biological Quality Tube Formation Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Cilium Movement Adult Behavior Regulation Of Macromolecule Biosynthetic Process	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Eukaryotic Translation Initiation Factor 3 Complex Ubiquitin-dependent Protein Catabolic Process Proteolysis Modification-dependent Protein Catabolic Process Protein Ubiquitination ATP Binding Proteolysis Involved In Protein Catabolic Process Translation Initiation Factor Activity Protein Modification Process Nucleotide Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Translational Initiation Enzyme Binding Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Positive Regulation Of Anion Channel Activity Macromolecule Catabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Macrophage Migration Inhibitory Factor Binding Proteasomal Protein Catabolic Process Cyclin D2-CDK4 Complex Positive Regulation Of Monoatomic Anion Transport Translation Reinitiation Multi-eIF Complex Cytosol Positive Regulation Of Enamel Mineralization Exosomal Secretion Transepithelial Water Transport Protein Catabolic Process Viral Translational Termination-reinitiation HULC Complex Cellular Response To Ionomycin Positive Regulation Of Tooth Mineralization DeNEDDylase Activity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Molecular Adaptor Activity Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Transcription Elongation Factor Activity
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