LAMTOR3 and BHMT

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LAMTOR3	BHMT
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	betaine--homocysteine S-methyltransferase
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GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Endosome Late Endosome Plasma Membrane Focal Adhesion Endosome Membrane Membrane Late Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex FNIP-folliculin RagC/D GAP	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity	Methyltransferase Activity S-methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Betaine-homocysteine S-methyltransferase Activity
	Biological Process	Intracellular Protein Localization Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Positive Regulation Of MAPK Cascade Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of TORC1 Signaling	Protein Methylation Modified Amino Acid Metabolic Process Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Methionine Biosynthetic Process Methylation S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process 'de Novo' L-methionine Biosynthetic Process L-methionine Salvage
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1	Sulfur amino acid metabolism Choline catabolism
Drugs			Methionine S-(D-Carboxybutyl)-L-Homocysteine Betaine
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23378610 23823483) Serum metabolite levels ( 33031748) Toenail selenium levels ( 25343990)
Interacting Genes		20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4	6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5
Entrez ID		8649	635
HPRD ID		04485	04200
Ensembl ID		ENSG00000109270	ENSG00000145692
Uniprot IDs		Q9UHA4	Q93088 V9HWA4
PDB IDs		1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB	1LT7 1LT8 4M3P 8D45
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Regulation Of Golgi Organization Trachea Formation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Animal Organ Formation Face Development ERBB2 Signaling Pathway Lung Morphogenesis Thyroid Gland Development Insulin-like Growth Factor Receptor Signaling Pathway Bergmann Glial Cell Differentiation Thymus Development ERK1 And ERK2 Cascade Late Endosome Glial Cell Development ERBB Signaling Pathway Myelination Interleukin-34-mediated Signaling Pathway Axon Ensheathment Hematopoietic Or Lymphoid Organ Development Astrocyte Differentiation Regulation Of Intracellular Transport Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Epithelial Cell Proliferation Involved In Lung Morphogenesis Cardiac Neural Crest Cell Development Involved In Heart Development Outer Ear Morphogenesis Molecular Adaptor Activity Regulation Of MAPK Cascade MAP-kinase Scaffold Activity MAPK Cascade MAP Kinase Kinase Activity MAP Kinase Activity Pseudopodium Regulation Of DNA-templated Transcription Gland Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Macrophage Chemotaxis Glial Cell Differentiation Positive Regulation Of Neuroinflammatory Response Regulation Of Cellular Localization Regulation Of Cellular Response To Stress Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cytoplasm	BBSome Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Cilium Beat Frequency Striatum Development Brain Morphogenesis Regulation Of Cilium Movement Photoreceptor Cell Maintenance Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Ciliary Membrane Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Ragulator Complex Hippocampus Development Cerebral Cortex Development FNIP-folliculin RagC/D GAP Leptin-mediated Signaling Pathway Negative Regulation Of Appetite Fat Cell Differentiation Centriolar Satellite Adult Behavior Regulation Of Response To Food Retina Homeostasis Response To Leptin Ventricular System Development Protein Localization To Organelle Visual Perception Sensory Perception Of Light Stimulus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Appetite Pigment Granule Localization Motile Cilium Positive Regulation Of Multicellular Organism Growth Regulation Of Response To Nutrient Levels Intracellular Protein Localization Golgi To Plasma Membrane Protein Transport Regulation Of Microtubule-based Process Cilium Assembly Cilium Organization Dendrite Development Establishment Of Protein Localization To Plasma Membrane Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Localization To Cilium Golgi To Plasma Membrane Transport TORC1 Signaling Positive Regulation Of TORC1 Signaling
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