EIF4EBP3 and BBS5

		EIF4EBP3	BBS5
Description		eukaryotic translation initiation factor 4E binding protein 3	Bardet-Biedl syndrome 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Eukaryotic Translation Initiation Factor 4F Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Ciliary Membrane
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity	Protein Binding Phosphatidylinositol-3-phosphate Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Translation Negative Regulation Of Translation Negative Regulation Of Translational Initiation	Heart Looping Visual Perception Protein Transport Cell Projection Organization Melanosome Transport Motile Cilium Assembly Intracellular Transport Cilium Assembly
Pathways			BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Metabolite levels ( 23823483) Serum immune biomarker levels ( 32066700)	Iris heterochromicity ( 30895295)
Interacting Genes		3 interacting genes: BBS5 EIF4E EIF4E2	15 interacting genes: CFAP210 COTL1 CRADD CTSK EIF4EBP3 HRH1 KLC3 KLHL23 KLHL41 ORM2 PRDM2 SLC6A15 TOM1 TOM1L2 UBR3
Entrez ID		8637	129880
HPRD ID		09149	10353
Ensembl ID		ENSG00000243056	ENSG00000163093
Uniprot IDs		O60516	A0A0S2Z626 Q8N3I7
PDB IDs			6XTB
Enriched GO Terms of Interacting Partners?		MRNA Cap Binding RNA Cap Binding RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Translation Initiation Factor Activity Translational Initiation P-body Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Translation Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse Translation BBSome Regulation Of Translation Chromatoid Body Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Translation Factor Activity, RNA Binding Negative Regulation Of Type I Interferon-mediated Signaling Pathway Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Melanosome Transport Pigment Granule Localization Cellular Response To Dexamethasone Stimulus Postsynaptic Modulation Of Chemical Synaptic Transmission Behavioral Fear Response Behavioral Defense Response Rescue Of Stalled Ribosome
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