PDE8B and SSBP2

		PDE8B	SSBP2
Description		phosphodiesterase 8B	single stranded DNA binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	DNA Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Behavioral Fear Response CAMP Catabolic Process Signal Transduction Visual Learning Operant Conditioning Negative Regulation Of Insulin Secretion Neuromuscular Process Controlling Balance Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Steroid Hormone Biosynthetic Process Negative Regulation Of CAMP/PKA Signal Transduction	Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		G alpha (s) signalling events
Drugs		Caffeine Trapidil
Diseases		Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Autoimmune thyroid disease ( 32581359) Caudate nucleus volume ( 21502949) Chronotype ( 30696823) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hyperthyroidism ( 30367059) Hypothyroidism ( 27182965 30367059 22493691) Medication use (thyroid preparations) ( 31015401) Serum thyroid-stimulating hormone levels ( 25436638) Sjögren's syndrome ( 28076899) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335 32769997 18514160)	Adult body size ( 32376654) Anorexia nervosa ( 21079607) Bipolar disorder ( 31043756 33263727 34002096) Glioblastoma ( 22472174) HDL cholesterol levels in HIV infection ( 33109212) Plateletcrit ( 32888494)
Interacting Genes			7 interacting genes: CDK6 EWSR1 IL36RN LDB1 LDB2 PIN1 TOM1
Entrez ID		8622	23635
HPRD ID		04546	09577
Ensembl ID		ENSG00000113231	ENSG00000145687
Uniprot IDs		A0A2R8Y4E6 B3KN77 O95263	A0A087X159 P81877
PDB IDs			6IWV 6TYD 8HIB
Enriched GO Terms of Interacting Partners?		Pigment Granule Aggregation In Cell Center Primary Palate Development BBSome Pigment Granule Localization Establishment Of Melanosome Localization Digestive Tract Morphogenesis Melanosome Localization Melanosome Transport Pigment Granule Transport	LIM Domain Binding Transcription Coregulator Activity Regulation Of Metabolic Process Epithelial Structure Maintenance Negative Regulation Of Metabolic Process Regulation Of Erythrocyte Differentiation Cyclin D2-CDK6 Complex Cis-trans Isomerase Activity Cell Leading Edge Hair Follicle Development Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Establishment Of Protein Localization To Mitochondrion Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Somatic Stem Cell Population Maintenance Hair Cycle Process Myosin VI Binding Negative Regulation Of Biosynthetic Process
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