PDE8B

Description		phosphodiesterase 8B
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Behavioral Fear Response CAMP Catabolic Process Signal Transduction Visual Learning Operant Conditioning Negative Regulation Of Insulin Secretion Neuromuscular Process Controlling Balance Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Steroid Hormone Biosynthetic Process Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		G alpha (s) signalling events
Drugs		Caffeine Trapidil
Diseases		Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Autoimmune thyroid disease ( 32581359) Caudate nucleus volume ( 21502949) Chronotype ( 30696823) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hyperthyroidism ( 30367059) Hypothyroidism ( 27182965 30367059 22493691) Medication use (thyroid preparations) ( 31015401) Serum thyroid-stimulating hormone levels ( 25436638) Sjögren's syndrome ( 28076899) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335 32769997 18514160)
Novel Interacting Genes		2 novel interacting genes: BBS7 SSBP2
Interacting Genes
Entrez ID		8622
HPRD ID		04546
Ensembl ID		ENSG00000113231
Uniprot IDs		A0A2R8Y4E6 B3KN77 O95263
PDB IDs
Enriched GO Terms of Interacting Partners?		Pigment Granule Aggregation In Cell Center Primary Palate Development BBSome Pigment Granule Localization Establishment Of Melanosome Localization Digestive Tract Morphogenesis Melanosome Localization Melanosome Transport Pigment Granule Transport
Tagcloud ?