CDK13 and PRPF40A

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDK13	PRPF40A
Description		cyclin dependent kinase 13	pre-mRNA processing factor 40A
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK13 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Golgi Apparatus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Protein Kinase Binding Cyclin Binding Protein Serine Kinase Activity	RNA Binding Protein Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of Signal Transduction Hemopoiesis Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Negative Regulation Of Stem Cell Differentiation	MRNA Splicing, Via Spliceosome MRNA Processing Cytoskeleton Organization Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division
Pathways		TP53 Regulates Transcription of DNA Repair Genes Neutrophil degranulation	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Plateletcrit ( 32888494) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: C1QBP CEBPA CHMP4A KRT31 PRPF40A RNF10 SRPK2 SRSF1 TRIM7	132 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTBP1 PTPRF RBM39 RBMX2 RCC2 RLF RNF10 RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B2 SF3B3 SFPQ SMAD4 SNIP1 SNRNP70 SON SPMIP2 SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 TMEM132D U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 USP7 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451
Entrez ID		8621	55660
HPRD ID		04496	10995
Ensembl ID		ENSG00000065883	ENSG00000196504
Uniprot IDs		Q14004 Q9BVE2	A0A7N4I394 A0A8Q3SIG7 A0A8V8TM61 F5H578 O75400
PDB IDs		5EFQ 7NXJ	1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS 8PXW 8PXX
Enriched GO Terms of Interacting Partners?		RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Processing Regulation Of RNA Splicing MRNA Metabolic Process Macromolecule Metabolic Process RNA Metabolic Process Animal Organ Regeneration Organelle Organization Adrenergic Receptor Binding Regulation Of MRNA Metabolic Process RNA Processing RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Kininogen Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Vitamin B2 C/EBP Complex Protein Localization To P-body Nucleus Organization Nuclear Speck Negative Regulation Of MRNA Metabolic Process Liver Development C5-methylcytidine-containing RNA Reader Activity Deoxyribonuclease Inhibitor Activity Negative Regulation Of MDA-5 Signaling Pathway Nucleic Acid Metabolic Process CHOP-C/EBP Complex Nuclear Matrix Regeneration White Fat Cell Proliferation Regulation Of Cell Cycle DNA Topoisomerase Binding Nuclear Speck Organization Nucleus Cytosolic Ribosome Assembly Positive Regulation Of Gene Expression Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Mitochondrial Ribosome Binding Positive Regulation Of Trophoblast Cell Migration RS Domain Binding	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Nuclear Speck Nucleic Acid Binding Spliceosomal Complex Nucleoplasm Nucleus Spliceosomal Complex Assembly RNA Metabolic Process U2 SnRNP Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly Actin Binding U2-type Precatalytic Spliceosome Profilin Binding SCAR Complex Cellular Component Assembly Actin Polymerization Or Depolymerization Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex MRNA 3'-splice Site Recognition Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-RNA Complex Assembly Actin Filament-based Process Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Metabolic Process Protein Binding Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Macromolecule Metabolic Process PML Body SUMO Ligase Activity Cytosol U2-type Spliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process Actin Cytoskeleton Organization Focal Adhesion Regulation Of Metabolic Process U2-type Prespliceosome CRD-mediated MRNA Stability Complex
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