PLPP3 and BCAR1

Number of citations of the paper that reports this interaction (PubMedID 16099422)
0

Data Source:
HPRD (in vitro)

		PLPP3	BCAR1
Description		phospholipid phosphatase 3	BCAR1 scaffold protein, Cas family member
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Adherens Junction Membrane Basolateral Plasma Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Raft Endoplasmic Reticulum Exit Site	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Axon Cell Projection Anchoring Junction
	Molecular Function	Integrin Binding Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Delta-catenin Binding Ceramide-1-phosphate Phosphatase Activity	Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Blood Vessel Development Gastrulation With Mouth Forming Second Lipid Metabolic Process Phospholipid Metabolic Process Sphingosine Metabolic Process Ceramide Metabolic Process Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Cell Adhesion Signal Transduction Integrin-mediated Signaling Pathway Positive Regulation Of Endothelial Cell Migration Regulation Of Wnt Signaling Pathway Sphingolipid Catabolic Process Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Phospholipid Dephosphorylation Protein Stabilization Bergmann Glial Cell Differentiation Cell-cell Adhesion Regulation Of Sphingolipid Mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway
Pathways		Sphingolipid catabolism	Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) Heel bone mineral density ( 30598549) Low density lipoprotein cholesterol levels ( 29403010) Myocardial infarction ( 33532862) Retinitis pigmentosa ( 33514863)	Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 33020668) Crohn's disease (time to surgery) ( 23665963) Intracranial aneurysm ( 33199917) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Pancreatic cancer ( 25086665 29422604) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)
Interacting Genes		4 interacting genes: APP BCAR1 CTNND1 SHC1	65 interacting genes: ABL1 AJUBA ANKS1A ARHGAP32 BMX CASP3 CD2AP COPB1 CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EEIG1 EFS ESR1 FAM90A1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NCK2 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PRAM1 PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 USP2 VCL VPS11 YES1 YWHAZ
Entrez ID		8613	9564
HPRD ID		06179	04248
Ensembl ID		ENSG00000162407	ENSG00000050820
Uniprot IDs		O14495	B3KWE2 P56945
PDB IDs			1WYX 3T6G 5O2M 5O2P 5O2Q
Enriched GO Terms of Interacting Partners?		Insulin Receptor Binding Ephrin Receptor Binding Cellular Response To Growth Factor Stimulus Cell Adhesion Regulation Of Superoxide Metabolic Process Response To Growth Factor Anchoring Junction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Blood Vessel Branching Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Shc-EGFR Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERK1 And ERK2 Cascade Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Protein Localization To Cell-cell Junction Positive Regulation Of Cell Proliferation In Bone Marrow Epidermal Growth Factor Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Multicellular Organismal Process Regulation Of Spontaneous Synaptic Transmission	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Focal Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Cell Migration Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Signal Transduction Cell Motility Regulation Of Cell-substrate Adhesion Ephrin Receptor Signaling Pathway Anchoring Junction Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Regulation Of Immune System Process Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Tyrosine Kinase Activity Fc Receptor Mediated Stimulatory Signaling Pathway Plasma Membrane Immune Response-activating Signaling Pathway Regulation Of Cell Motility Antigen Receptor-mediated Signaling Pathway SH3 Domain Binding Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Migration Fc Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell-matrix Adhesion Intracellular Signal Transduction Cytosol Regulation Of Cytoskeleton Organization Cytoplasm Regulation Of Signal Transduction Cell Adhesion Cell-cell Junction Regulation Of Cell Junction Assembly Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?