NOP14 and NSD2

		NOP14	NSD2
Description		NOP14 nucleolar protein	nuclear receptor binding SET domain protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane 90S Preribosome Noc4p-Nop14p Complex Small-subunit Processome	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm
	Molecular Function	RNA Binding Enzyme Binding SnoRNA Binding	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K36 Trimethyltransferase Activity
	Biological Process	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 5'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases			Multiple myeloma
GWAS		Household income (MTAG) ( 31844048) Huntington's disease progression ( 28642124) Smoking behaviour (cigarettes smoked per day) ( 30679032)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		3 interacting genes: CEBPA NSD2 RNF10	20 interacting genes: AGO2 APP AR AURKA BRCA1 ESR1 H19 H3-4 H3C1 H3C14 HORMAD2 MDC1 NELFA NOP14 PCNA PLEKHF2 SH3BP2 SLBP SMURF1 TP53
Entrez ID		8602	7468
HPRD ID		12827	04259
Ensembl ID		ENSG00000087269	ENSG00000109685
Uniprot IDs		A8KA74 P78316	O96028
PDB IDs			5LSU 5VC8 6UE6 6XCG 7CRO 7E8D 7LMT 7MDN 7VLN 9EXW 9EXX 9EXY 9GBF
Enriched GO Terms of Interacting Partners?		Transcription Cis-regulatory Region Binding CHOP-C/EBP Complex Positive Regulation Of Multicellular Organismal Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Cell Development Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Histone H3K36 Trimethyltransferase Activity Atrial Septum Secundum Morphogenesis Atrial Septum Primum Morphogenesis Histone H3K36 Dimethyltransferase Activity Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Positive Regulation Of Isotype Switching To IgA Isotypes Response To Phenylpropanoid Positive Regulation Of Nucleobase-containing Compound Metabolic Process Urea Cycle DNA Binding Positive Regulation Of Cell Activation STAT Family Protein Binding Fat Cell Proliferation Histone H4K20 Methyltransferase Activity Histone H3K36 Methyltransferase Activity Membranous Septum Morphogenesis Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Urea Metabolic Process Sequence-specific DNA Binding HMG Box Domain Binding Response To Lithium Ion Transcription By RNA Polymerase I Chromatin Binding Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Osteoblast Development Regulation Of Developmental Process Atrial Septum Morphogenesis Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Myelination Positive Regulation Of Biosynthetic Process Epithelial Cell Maturation Regulation Of Cell Activation	Chromatin Organization Nucleoplasm Enzyme Binding Chromatin Remodeling Chromatin Binding Regulation Of MiRNA Transcription Protein Heterodimerization Activity Regulation Of MiRNA Metabolic Process Molecular Function Activator Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Developmental Growth Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Reproductive Process Prostate Gland Growth Nuclear Body Mitotic DNA Damage Checkpoint Signaling Protein-DNA Complex Assembly Estrogen Response Element Binding Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Biosynthetic Process Chromosome Positive Regulation Of Reproductive Process Nucleus Macromolecule Metabolic Process Structural Constituent Of Chromatin Protein-containing Complex Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Core Promoter Sequence-specific DNA Binding Nucleic Acid Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Nucleosome Assembly DNA Binding Regulation Of Cellular Response To Stress Gene Expression Prostate Gland Epithelium Morphogenesis Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Cellular Response To Oxygen-containing Compound Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II
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