CAV1 and EDNRB

Number of citations of the paper that reports this interaction (PubMedID 12694195)
0

Data Source:
HPRD (in vitro, in vivo)

		CAV1	EDNRB
Description		caveolin 1	endothelin receptor type B
Image
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Membrane Caveolar Macromolecular Signaling Complex Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Nuclear Membrane
	Molecular Function	Signaling Receptor Binding Patched Binding Protein Binding Oxysterol Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Nitric-oxide Synthase Inhibitor Activity Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Protein Heterodimerization Activity Nitric-oxide Synthase Binding ATPase Binding Molecular Adaptor Activity Inward Rectifier Potassium Channel Inhibitor Activity Protein Sequestering Activity	G Protein-coupled Receptor Activity Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Angiogenesis Vasculogenesis Response To Hypoxia Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Regulation Of The Force Of Heart Contraction Glandular Epithelial Cell Differentiation Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Nitric Oxide Biosynthetic Process Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Bacterium Negative Regulation Of Signal Transduction Positive Regulation Of Calcium Ion Transport Into Cytosol Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cholesterol Efflux Protein Transport Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Fatty Acid Metabolic Process Cytokine-mediated Signaling Pathway Lipid Storage Cell Differentiation Regulation Of Blood Coagulation Cholesterol Transport Positive Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Maintenance Of Protein Location In Cell Response To Progesterone Intracellular Nitric Oxide Homeostasis Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Insulin Receptor Internalization Angiotensin-activated Signaling Pathway Vasoconstriction Cholesterol Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Response To Estrogen Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Nitric Oxide Metabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Muscle Cell Cellular Homeostasis Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Pinocytosis Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Establishment Of Localization In Cell Membrane Depolarization Calcium Ion Homeostasis Mammary Gland Involution Canonical Wnt Signaling Pathway Negative Regulation Of Necroptotic Process Caveola Assembly Cellular Response To Misfolded Protein Cellular Response To Peptide Hormone Stimulus Cellular Response To Hyperoxia Cellular Response To Transforming Growth Factor Beta Stimulus Basement Membrane Organization Caveolin-mediated Endocytosis Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Cold-induced Thermogenesis Regulation Of Ruffle Assembly Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Localization To Basolateral Plasma Membrane Positive Regulation Of Gap Junction Assembly Positive Regulation Of ERAD Pathway Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Renin Secretion Into Blood Stream Regulation Of Heart Rate Regulation Of PH Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Gene Expression Negative Regulation Of Neuron Maturation Vein Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Calcium-mediated Signaling CGMP-mediated Signaling Heparin Proteoglycan Metabolic Process Melanocyte Differentiation Regulation Of Fever Generation Aldosterone Metabolic Process Response To Lipopolysaccharide Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Developmental Pigmentation Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Sodium Ion Homeostasis Canonical Wnt Signaling Pathway Positive Regulation Of Penile Erection Establishment Of Endothelial Barrier Renal Sodium Ion Absorption Calcium Ion Transmembrane Transport Cellular Response To Lipopolysaccharide Protein Transmembrane Transport Podocyte Differentiation Endothelin Receptor Signaling Pathway Renal Albumin Absorption Neuroblast Migration Chordate Pharynx Development Response To Sodium Phosphate Response To Endothelin
Pathways		Triglyceride catabolism eNOS activation NOSTRIN mediated eNOS trafficking Thyroxine biosynthesis Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle FOXO-mediated transcription of cell cycle genes RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways	Peptide ligand-binding receptors G alpha (q) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Bosentan IRL-1620 Sitaxentan Ambrisentan Enrasentan Tezosentan Macitentan
Diseases		Congenital generalized lipodystrophy (CGL)	Hirschsprung disease (HD) Waardenburg syndrome (WS) ABCD syndrome Nasopharyngeal cancer
GWAS		Atrial fibrillation ( 33990960 22544366 30061737 29892015 28416822) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063 25055868) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 25173105 29891935 33627673 20835238) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 29235454 25173106 28073927 29617998) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) P wave duration ( 28794112) Platelet distribution width ( 32888494) PR interval ( 20062060 25035420 32439900 30679814 23139255 30046033 29127183) PR segment duration ( 24850809) Proportion of activated microglia (inferior temporal cortex) ( 30679421) QRS duration ( 30012220) QT interval ( 29874175 24952745) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Appendicular lean mass ( 33097823) Craniofacial microsomia ( 26853712) Hair color ( 23548203 29662168) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		88 interacting genes: ABCB1 ABL1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DANCR DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FOXP2 FYN GJA1 GJA3 GJB2 GLP1R GNAI2 GRB7 GRK1 GRK2 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KCNA3 KDR LRP1 MALL MAPK1 MAPK3 MET MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TEK TGFBR1 TNFRSF1B TRAF2 TRAF4 TRAF6 TRPC1 USP7 VAV2	8 interacting genes: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 MYCBP2 NOS3
Entrez ID		857	1910
HPRD ID		03028	08834
Ensembl ID		ENSG00000105974	ENSG00000136160
Uniprot IDs		A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3	P24530
PDB IDs		7SC0	5GLH 5GLI 5X93 5XPR 6IGK 6IGL 6LRY 8HBD 8HCX 8IY5 8IY6 8XGR 8XVE 8XVH 8XWP 8XWQ 8ZRT
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Locomotion Regulation Of Multicellular Organismal Process Membrane Raft Regulation Of Cellular Component Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Oxygen-containing Compound Regulation Of Programmed Cell Death Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Biological Quality Kinase Activity Protein Phosphorylation Regulation Of Transport Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Cell Death Membrane Anatomical Structure Morphogenesis Phosphorylation Receptor Complex Regulation Of ERK1 And ERK2 Cascade	Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Blood Vessel Diameter Maintenance Vasoconstriction Regulation Of Tube Size Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure Vein Smooth Muscle Contraction Regulation Of Heart Contraction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Muscle System Process Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Blood Circulation Regulation Of Blood Coagulation Vascular Process In Circulatory System Regulation Of Hemostasis Regulation Of Potassium Ion Transport Regulation Of Developmental Process Circulatory System Process Artery Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Tonic Smooth Muscle Contraction Regulation Of Heart Rate Endothelin Receptor Signaling Pathway Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Vascular Associated Smooth Muscle Contraction Guanyl Nucleotide Binding Regulation Of Wound Healing Regulation Of Cell Migration Positive Regulation Of Hormone Secretion Regulation Of Cell Motility Nitric Oxide Biosynthetic Process G-protein Beta/gamma-subunit Complex Binding Regulation Of Muscle Contraction Regulation Of Response To Wounding Regulation Of The Force Of Heart Contraction Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cell Migration Regulation Of System Process Intracellular Calcium Ion Homeostasis Positive Regulation Of Heart Rate Negative Regulation Of Potassium Ion Transport Positive Regulation Of Cell Motility Nitric Oxide Metabolic Process Positive Regulation Of Smooth Muscle Contraction
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