YARS1 and USP25

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		YARS1	USP25
Description		tyrosyl-tRNA synthetase 1	ubiquitin specific peptidase 25
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GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Nuclear Body	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Tyrosine-tRNA Ligase Activity Interleukin-8 Receptor Binding Protein Binding ATP Binding Ligase Activity Small Molecule Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding Deubiquitinase Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Tyrosyl-tRNA Aminoacylation Apoptotic Process Response To Stress Response To Starvation Protein Poly-ADP-ribosylation	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Oxidative Stress Protein Modification Process Interleukin-17A-mediated Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Response To Oxidative Stress Negative Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of ERAD Pathway
Pathways		Cytosolic tRNA aminoacylation	Ub-specific processing proteases
Drugs		Tyrosine Beta-(2-Naphthyl)-Alanine Resveratrol Tyrosinal N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE p-Benzoyl-L-phenylalanine 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Severe autoimmune type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		6 interacting genes: CDC42 ELANE ESR1 OGT REL USP25	38 interacting genes: ACTA1 ARMC8 CDC73 CNTN1 EIF4A3 FBXL17 FLNC GAPDH GDI1 MAGEB4 MAVS MID2 MT2A NAP1L3 NGEF PAX6 PUS10 RAD23A RAD23B RPS10-NUDT3 RSL1D1 SENP1 SKIL SNRNP70 SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS TNKS2 TUBB UBC UBE2I VPS45 YARS1 ZNF426 ZNF841
Entrez ID		8565	29761
HPRD ID		09153	05296
Ensembl ID		ENSG00000134684	ENSG00000155313
Uniprot IDs		A0A0S2Z4R1 P54577	Q9UHP3
PDB IDs		1N3L 1NTG 1Q11 4Q93 4QBT 5THH 5THL 7ROU	2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Pyroptotic Inflammatory Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phagocytic Vesicle Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Negative Regulation Of Gene Expression ATPase Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Negative Regulation Of Protein-containing Complex Assembly Storage Vacuole Cytosol Antibacterial Peptide Biosynthetic Process Negative Regulation Of Metabolic Process Inflammatory Response Neutrophil-mediated Killing Of Fungus Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Interleukin-17-mediated Signaling Pathway Apolipoprotein A-I Receptor Binding Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Neuropilin Signaling Pathway Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth NF-kappaB Complex Protein-containing Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Ubiquitin-like Protein Peptidase Activity Non-canonical Inflammasome Complex Assembly Regulation Of Proteasomal Protein Catabolic Process	Presynaptic Cytosol Protein Tag Activity Protein Sumoylation Postsynaptic Cytosol Nucleus Post-translational Protein Modification Protein Modification By Small Protein Conjugation PML Body Protein Poly-ADP-ribosylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding Positive Regulation Of Telomere Capping Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Glutamatergic Synapse Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Regulation Of Telomere Capping Protein Localization To Organelle Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Cytosol Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Proteasome Binding Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-specific Protease Binding Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding Nuclear Pore NAD+-protein Mono-ADP-ribosyltransferase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Response To Cytokine
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