DEGS1 and SEMA4G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DEGS1	SEMA4G
Description		delta 4-desaturase, sphingolipid 1	semaphorin 4G
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Mitochondrial Membrane Specific Granule Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Electron Transfer Activity Oxidoreductase Activity Isomerase Activity Sphingolipid Delta-4 Desaturase Activity Retinol Isomerase Activity	Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Sphingolipid Biosynthetic Process Myelin Maintenance Ceramide Biosynthetic Process	Neural Crest Cell Migration Nervous System Development Axon Guidance Cell Differentiation Positive Regulation Of Cell Migration Negative Chemotaxis Semaphorin-plexin Signaling Pathway
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation
Drugs
Diseases
GWAS		Red blood cell count ( 32888494)	Regular attendance at a pub or social club ( 29970889)
Interacting Genes		5 interacting genes: CFTR DISC1 EGFR NAGPA SEMA4G	12 interacting genes: ARL13B ATXN1 CAMK2B CREB3L1 DEGS1 DLG4 GOPC LIG4 RBPMS TNFRSF10D TRIP13 ZDHHC17
Entrez ID		8560	57715
HPRD ID		13133	10218
Ensembl ID		ENSG00000143753	ENSG00000095539
Uniprot IDs		O15121	Q9NTN9 Q9NWU8
PDB IDs
Enriched GO Terms of Interacting Partners?		Telencephalon Cell Migration Cerebral Cortex Cell Migration Forebrain Cell Migration Clathrin-coated Endocytic Vesicle Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multivesicular Body, Internal Vesicle Lumen N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Cell Growth Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Positive Regulation Of Wnt Signaling Pathway Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Positive Regulation Of Enamel Mineralization Epidermal Growth Factor Binding Early Endosome Membrane Transepithelial Water Transport Regulation Of Protein Kinase C Signaling Cell Migration Secretion Of Lysosomal Enzymes Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Basolateral Plasma Membrane Positive Regulation Of Growth ERBB2-EGFR Signaling Pathway Cell Motility Radial Glia-guided Pyramidal Neuron Migration Cerebral Cortex Radial Glia-guided Migration Amelogenesis Endosome Membrane ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Salivary Gland Morphogenesis Ciliary Basal Body Regulation Of Wnt Signaling Pathway Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Response To UV-A Negative Regulation Of Cardiocyte Differentiation Golgi-associated Vesicle Membrane Eyelid Development In Camera-type Eye	Golgi-associated Vesicle Membrane Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Neurogenesis Postsynaptic Density Positive Regulation Of Nervous System Development Identical Protein Binding Regulation Of Long-term Neuronal Synaptic Plasticity P2Y1 Nucleotide Receptor Binding Social Behavior Establishment Of Integrated Proviral Latency Sphingolipid Delta-4 Desaturase Activity Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Anion Channel Activity
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