PIAS1 and HIC1

Number of citations of the paper that reports this interaction (PubMedID 17283066)
64

Data Source:
BioGRID (enzymatic study)

		PIAS1	HIC1
Description		protein inhibitor of activated STAT 1	HIC ZBTB transcriptional repressor 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytoskeleton PML Body Nuclear Speck Nuclear Periphery Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Metal Ion Binding SUMO Ligase Activity DNA-binding Transcription Factor Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Regulation Of Transcription By RNA Polymerase II DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Visual Learning Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Positive Regulation Of Protein Localization To Cell Periphery	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling	SUMOylation of transcription factors
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Haemorrhoidal disease ( 33888516) Major depressive disorder ( 23377640) Number of twin births ( 30760885)	Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 27863252) Plateletcrit ( 27863252 32888494) Spleen volume ( 34128465)
Interacting Genes		118 interacting genes: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CASP8 CBS CDK4 CEBPA CEBPE CHD3 CHUK CNOT7 CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 EP300 ERG ESR1 ESR2 FANCI FHL3 FLI1 GATA4 GLUL GRM8 GSK3B GTF2IRD1 H2AZ1 H2BC3 H3C1 HECTD2 HIC1 HTT IKZF5 JUN L3MBTL2 LSM3 MAML1 MBD1 MDC1 MDM2 MITF MORC3 MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 NRIP1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRPF40A PTK2 PTPN1 QKI RAD51 RAD54L2 RBBP6 RELA RHOB RPA2 SATB1 SATB2 SERBP1 SETX SGTA SKIL SMAD1 SMAD4 SMAD7 SNAI2 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO1P1 SUMO2 SUMO3 TBP TERF2 TERF2IP TEX11 TP53 TP73 TRIM27 TRIM5 TRIM55 TRIM63 TSG101 UBE2I UBE2L3 YWHAZ ZBED1 ZNF451 ZNF76	12 interacting genes: ARID1A CRBN CTBP1 CTBP2 HDAC1 HIC2 MECOM PIAS1 SENP3 SIRT1 TCF7L2 UBE2I
Entrez ID		8554	3090
HPRD ID		16029	04826
Ensembl ID		ENSG00000033800	ENSG00000177374
Uniprot IDs		O75925	A0PJI1 Q14526
PDB IDs		1V66
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression DNA Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin PML Body Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Enzyme Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Sumoylation Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Stress Cellular Response To Stress RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Cellular Response To Stress Nucleic Acid Metabolic Process Chromatin Binding Intracellular Signal Transduction SUMO Transferase Activity	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Corepressor Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Binding Transcription Corepressor Activity White Fat Cell Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process PML Body Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway HLH Domain Binding Transcription Coregulator Binding Nuclear Receptor Binding Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Repressor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Promoter-specific Chromatin Binding Nucleoplasm Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Protein Modification Process Transcription Coactivator Activity Protein Deacetylation Protein Lysine Deacetylase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Histone Deacetylase Activity Viral Genome Replication SUMO Transferase Activity Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?