MAPKAPK5 and ZNF282

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPKAPK5	ZNF282
Description		MAPK activated protein kinase 5	zinc finger protein 282
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Nucleus
	Molecular Function	Nucleotide Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Dendritic Spine Development Cellular Senescence Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction	Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription
Pathways		Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation	Generic Transcription Pathway
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254) Spleen volume ( 34128465) Tea consumption ( 33080986)	Eosinophil count ( 32888494) Hip circumference ( 28552196)
Interacting Genes		32 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HMGB1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SNCA SRPK1 SRPK2 TAB1 TP53 YAP1 ZNF282 ZNF576	3 interacting genes: MAPKAPK5 PIK3CG PKN1
Entrez ID		8550	8427
HPRD ID		09467	04549
Ensembl ID		ENSG00000089022	ENSG00000170265
Uniprot IDs		Q8IW41	A0A090N8Y3 Q86YG2 Q9UDV7
PDB IDs
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity MAPK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Cellular Response To Anisomycin Cytosol Kinase Activity Positive Regulation Of Cytokine Production Response To Anisomycin Nucleus Stress-activated MAPK Cascade Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Response To Stress Cellular Response To Stress Phosphorylation Cytoplasm Animal Organ Development Regulation Of Gene Expression Regulation Of Cytokine Production Regulation Of Macromolecule Biosynthetic Process Phosphate-containing Compound Metabolic Process Protein Localization To Tricellular Tight Junction Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process ATP Binding Positive Regulation Of Biosynthetic Process Cellular Senescence Positive Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia P38MAPK Cascade Cellular Response To Radiation Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Postsynapse Cellular Response To Oxygen-containing Compound Cellular Response To UV RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Apoptotic Process Transferase Activity Nucleotide Binding Cellular Response To Oxidative Stress Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Response To Oxidative Stress	Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Nucleotide Binding ATP Binding Phosphate-containing Compound Metabolic Process Natural Killer Cell Chemotaxis Negative Regulation Of Cardiac Muscle Contraction Phosphatidylinositol 3-kinase Complex, Class IB Negative Regulation Of Striated Muscle Contraction Respiratory Burst Involved In Defense Response Phosphatidylinositol 3-kinase Complex Negative Regulation Of Triglyceride Catabolic Process 1-phosphatidylinositol-4-phosphate 3-kinase Activity Regulation Of Intracellular Signal Transduction Transferase Activity Intracellular Signal Transduction Negative Regulation Of Fibroblast Apoptotic Process Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Neutrophil Extravasation Regulation Of Germinal Center Formation Phosphorylation Protein Phosphorylation Histone H3T11 Kinase Activity Stress-induced Premature Senescence Septin Cytoskeleton Calcium-dependent Protein Serine/threonine Kinase Activity 1-phosphatidylinositol-3-kinase Activity B Cell Apoptotic Process Positive Regulation Of Biosynthetic Process Hepatocyte Apoptotic Process Regulation Of Fibroblast Apoptotic Process Secretory Granule Localization Positive Regulation Of Rac Protein Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Dendritic Cell Chemotaxis T Cell Chemotaxis Negative Regulation Of Muscle Contraction Respiratory Burst Negative Regulation Of Triglyceride Metabolic Process Negative Regulation Of Heart Contraction Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Cellular Extravasation Regulation Of Developmental Process Negative Regulation Of B Cell Proliferation Diacylglycerol-dependent Serine/threonine Kinase Activity
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