AGPS and PDE11A

		AGPS	PDE11A
Description		alkylglycerone phosphate synthase	phosphodiesterase 11A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane	Cytoplasm Cytosol
	Molecular Function	Catalytic Activity Protein Binding Alkylglycerone-phosphate Synthase Activity Transferase Activity Flavin Adenine Dinucleotide Binding FAD Binding	Catalytic Activity Cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Lipid Metabolic Process Lipid Biosynthetic Process Ether Lipid Biosynthetic Process	Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Plasmalogen biosynthesis Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	cGMP effects G alpha (s) signalling events
Drugs			Caffeine Tadalafil Trapidil
Diseases		Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Height ( 28552196)	Adiponectin levels x Mediterranean diet adherence interaction ( 33562295) Appendicular lean mass ( 33097823) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Diastolic blood pressure ( 29212154) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 20881960 28552196) High myopia ( 31816047 33830181) Hip circumference adjusted for BMI ( 34021172) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30224653)
Interacting Genes		2 interacting genes: GNPAT GORASP1
Entrez ID		8540	50940
HPRD ID		04337	05391
Ensembl ID		ENSG00000018510	ENSG00000128655
Uniprot IDs		B7Z3Q4 O00116	Q9HCR9
PDB IDs
Enriched GO Terms of Interacting Partners?			Alkylglycerone-phosphate Synthase Activity Ether Lipid Biosynthetic Process FK506 Binding Ether Lipid Metabolic Process FAD Binding Peptidyl-prolyl Cis-trans Isomerase Activity Peroxisomal Matrix Peroxisomal Membrane Flavin Adenine Dinucleotide Binding Peroxisome Isomerase Activity
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