PDE11A

Description		phosphodiesterase 11A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Catalytic Activity Cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		cGMP effects G alpha (s) signalling events
Drugs		Caffeine Tadalafil Trapidil
Diseases		Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Adiponectin levels x Mediterranean diet adherence interaction ( 33562295) Appendicular lean mass ( 33097823) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Diastolic blood pressure ( 29212154) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 20881960 28552196) High myopia ( 31816047 33830181) Hip circumference adjusted for BMI ( 34021172) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30224653)
Novel Interacting Genes		2 novel interacting genes: AGPS FKBP7
Interacting Genes
Entrez ID		50940
HPRD ID		05391
Ensembl ID		ENSG00000128655
Uniprot IDs		Q9HCR9
PDB IDs
Enriched GO Terms of Interacting Partners?		Alkylglycerone-phosphate Synthase Activity Ether Lipid Biosynthetic Process FK506 Binding Ether Lipid Metabolic Process FAD Binding Peptidyl-prolyl Cis-trans Isomerase Activity Peroxisomal Matrix Peroxisomal Membrane Flavin Adenine Dinucleotide Binding Peroxisome Isomerase Activity
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