DGKD and TNFRSF14

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		DGKD	TNFRSF14
Description		diacylglycerol kinase delta	TNF receptor superfamily member 14
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Cytoplasmic Vesicle	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Kinase Binding Diacylglycerol Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding Receptor Ligand Activity
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Endocytosis Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Transport Platelet Activation Intracellular Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Diacylglycerol Metabolic Process Diacylglycerol Catabolic Process Phosphatidic Acid Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Clathrin-dependent Endocytosis	Adaptive Immune Response Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration
Pathways		Effects of PIP2 hydrolysis	TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA
Drugs		Phosphatidyl serine alpha-Tocopherol succinate
Diseases
GWAS		Appendicular lean mass ( 33097823) Bilirubin levels ( 20639394 32084209) Calcium levels ( 20705733 24068962 29403010) Crohn's disease ( 22412388) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 29891935) Kidney stones ( 31729369) Lymphocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30718926 32499647) Urinary calcium excretion ( 31993563)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Autoimmune thyroid disease ( 32581359) Body mass index ( 26426971) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 28445677) Primary sclerosing cholangitis ( 23603763) Rheumatoid arthritis ( 24390342 24449572 18794853 30423114) Ulcerative colitis ( 26398853 28067908 23128233 21297633)
Interacting Genes		10 interacting genes: DGKH DYSF FMR1 FXR2 HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14	39 interacting genes: A2M ANGPTL7 APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ENO1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MASP2 MBTPS1 NDST2 NDUFS2 NID2 NRIP1 POLR1A RAD21 RPL22 SERPINA4 SRM TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 UNC93A VIM WDR73 ZBTB48
Entrez ID		8527	8764
HPRD ID		03492	04122
Ensembl ID		ENSG00000077044	ENSG00000157873
Uniprot IDs		Q16760	B9A034 Q92956
PDB IDs		1R79 3BQ7	1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3 7MSG
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Positive Regulation Of Cell Development Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of MRNA Stability Regulation Of RNA Stability Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Nervous System Development Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Intracellular Transport Of Viral Material Positive Regulation Of Myeloid Leukocyte Differentiation Monocyte Activation Involved In Immune Response Dendritic Filopodium Cytoplasmic Ribonucleoprotein Granule Regulation Of Cell Development Regulation Of Neurotransmitter Secretion Signaling Adaptor Activity Regulation Of MRNA Metabolic Process Positive Regulation Of Cell Differentiation Histone H3 Reader Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Negative Regulation Of Adaptive Immune Memory Response SAM Domain Binding Regulation Of Translation Negative Regulation Of Long-term Synaptic Depression Cytoplasmic Stress Granule Growth Cone Filopodium Positive Regulation Of Multicellular Organismal Process Regulation Of Nervous System Development Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Positive Regulation Of Myeloid Cell Differentiation Regulation Of Myeloid Leukocyte Differentiation Protein Kinase C Signaling MRNA Transport MRNA 3'-UTR Binding RNA Strand Annealing Activity Presynaptic Membrane Regulation Of Neuronal Action Potential Regulation Of Angiotensin-activated Signaling Pathway Granulocyte Colony-stimulating Factor Signaling Pathway Neuronal Ribonucleoprotein Granule Negative Regulation Of Synaptic Vesicle Exocytosis RNA Transport Host-mediated Perturbation Of Viral RNA Genome Replication Regulation Of Vesicle-mediated Transport	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Identical Protein Binding CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Signaling Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Apoptotic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Tumor Necrosis Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Histone Deacetylase Complex Apoptotic Process Nitric-oxide Synthase Regulator Activity Programmed Cell Death Cell Death Transcription Corepressor Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Glial Cell Apoptotic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Apoptotic Signaling Pathway Enzyme Binding Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Immune System Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Type II Interferon Production Immune System Process Regulation Of ATP Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity
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