NIPSNAP1 and RGS2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		NIPSNAP1	RGS2
Description		nipsnap homolog 1	regulator of G protein signaling 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Membrane Synaptic Membrane	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Adenylate Cyclase Inhibitor Activity Beta-tubulin Binding
	Biological Process	Mitophagy Autophagy Sensory Perception Of Pain	Response To Amphetamine Regulation Of Translation G Protein-coupled Receptor Signaling Pathway Spermatogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of JNK Cascade Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Glycine Import Across Plasma Membrane
Pathways			G alpha (q) signalling events
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		4 interacting genes: DBI RGS2 TBC1D17 UBC	62 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A SUN2 TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		8508	5997
HPRD ID		10342	02917
Ensembl ID		ENSG00000184117	ENSG00000116741
Uniprot IDs		B4DQI7 Q9BPW8	P41220
PDB IDs			2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?		Protein-lipid Complex Negative Regulation Of Protein Lipidation Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Benzodiazepine Receptor Binding Regulation Of Protein Lipidation Long-chain Fatty Acyl-CoA Binding Negative Regulation Of Lipoprotein Metabolic Process Adenylate Cyclase Inhibitor Activity Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway GTPase Activator Activity Relaxation Of Smooth Muscle Relaxation Of Vascular Associated Smooth Muscle Regulation Of Lipoprotein Metabolic Process Phosphatidylcholine Acyl-chain Remodeling Fatty-acyl-CoA Binding Positive Regulation Of Phospholipid Transport Negative Regulation Of Amino Acid Transport Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of Striated Muscle Contraction Relaxation Of Cardiac Muscle Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Smooth Muscle Contraction Protein Tag Activity Perinuclear Endoplasmic Reticulum Relaxation Of Muscle Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Muscle Contraction Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Protein Metabolic Process Brown Fat Cell Differentiation G-protein Alpha-subunit Binding Response To Amphetamine Maternal Process Involved In Female Pregnancy Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of JNK Cascade Negative Regulation Of Organ Growth Positive Regulation Of Heart Contraction Regulation Of Cell Projection Organization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Beta-tubulin Binding Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Amine	Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Guanyl Nucleotide Binding Calyx Of Held G-protein Beta/gamma-subunit Complex Binding Cognition Nucleotide Binding Regulation Of Secretion By Cell Scaffold Protein Binding Protein-containing Complex Binding Learning Or Memory Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Regulation Of Transport Response To Ketone Regulation Of Secretion Enzyme Binding Histone H3T6 Kinase Activity Regulation Of Neurotransmitter Secretion Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Corticosterone Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis Regulation Of Insulin Secretion Regulation Of Muscle System Process Regulation Of Muscle Contraction Response To Alcohol Regulation Of Protein Secretion System Process Response To Catecholamine Cytoplasm Nervous System Process Adrenergic Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Exocytosis Response To Hormone Cellular Localization Protein Kinase C Signaling Membrane Regulation Of Peptide Hormone Secretion Establishment Of Localization In Cell Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization G Protein-coupled Receptor Signaling Pathway Centrosome Regulation Of Establishment Of Protein Localization Response To Psychosocial Stress Adenylate Cyclase Activator Activity Intracellular Protein Localization G Protein Activity
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