REPS1 and WWC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		REPS1	WWC2
Description		RALBP1 associated Eps domain containing 1	WW and C2 domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane	Cytoplasm Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity Metal Ion Binding	Protein Binding Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity
	Biological Process	Endocytosis Endosomal Transport	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Cell Migration Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Negative Regulation Of Organ Growth
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Type 2 diabetes ( 32499647)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Heel bone mineral density ( 30598549) Height ( 20881960 28552196) Initial alcohol sensitivity ( 30276832)
Interacting Genes		19 interacting genes: AKT1 ANKRD1 ATF4 CRK FLNC GRB2 HSF1 ITSN1 ITSN2 MZT1 PIN1 RAB11FIP2 RALA RALB RALBP1 REPS2 TRAPPC2 TRAPPC2L WWC2	5 interacting genes: CRYAA REPS1 WWC1 WWC3 YWHAQ
Entrez ID		85021	80014
HPRD ID		09687	12529
Ensembl ID		ENSG00000135597	ENSG00000151718
Uniprot IDs		B2R7D3 Q96D71	Q6AWC2
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Intracellular Signaling Cassette Import Into Cell Intracellular Signal Transduction Clathrin-dependent Synaptic Vesicle Endocytosis Cytosol Protein-macromolecule Adaptor Activity Small GTPase-mediated Signal Transduction Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Organelle Organization Signal Transduction Organelle Organization Cellular Response To Decreased Oxygen Levels Response To Decreased Oxygen Levels Regulation Of Organelle Organization Cellular Response To Oxygen Levels Response To Oxygen Levels Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling PERK-mediated Unfolded Protein Response Receptor Internalization Establishment Of Protein Localization To Mitochondrion General Transcription Initiation Factor Binding TRAPPII Protein Complex TRAPPIII Protein Complex ERBB Signaling Pathway Ras Protein Signal Transduction Regulation Of Innate Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Kinase Binding Cellular Localization Positive Regulation Of Protein Localization To Membrane Regulation Of Intracellular Signal Transduction TRAPP Complex Cytoplasm Positive Regulation Of Growth Positive Regulation Of Organelle Assembly Kinase Binding Positive Regulation Of Cellular Component Biogenesis Intracellular Vesicle Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Organization Response To Hypoxia	Hippo Signaling Negative Regulation Of Hippo Signaling Negative Regulation Of Organ Growth Regulation Of Hippo Signaling Signaling Adaptor Activity Kinase Binding Regulation Of Organ Growth Negative Regulation Of Developmental Growth Regulation Of Growth Negative Regulation Of Macromolecule Biosynthetic Process Molecular Adaptor Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Growth Lens Fiber Cell Morphogenesis Negative Regulation Of Macromolecule Metabolic Process Tubulin Complex Assembly Negative Regulation Of Metabolic Process Cytosol Response To UV-A Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Developmental Growth Lens Morphogenesis In Camera-type Eye Embryonic Camera-type Eye Morphogenesis Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transport Structural Constituent Of Eye Lens Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Hippo Signaling Apoptotic Process Involved In Morphogenesis
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