DISP1 and LAPTM5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DISP1	LAPTM5
Description		dispatched RND transporter family member 1	lysosomal protein transmembrane 5
Image			No pdb structure
GO Annotations	Cellular Component	Membrane	Lysosome Lysosomal Membrane Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Molecular Carrier Activity	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Protein Sequestering Activity
	Biological Process	Smoothened Signaling Pathway Patched Ligand Maturation Determination Of Left/right Symmetry Embryonic Pattern Specification Dorsal/ventral Pattern Formation Peptide Transport Diaphragm Development	Defense Response To Tumor Cell Positive Regulation Of Cytokine Production Involved In Immune Response Protein Targeting To Lysosome Intracellular Protein Transport Induction Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of MAPK Cascade Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of Macrophage Cytokine Production Protein Localization To Lysosome Golgi To Lysosome Transport Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Autophagic Cell Death Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor Catabolic Process
Pathways
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186)	Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: LAPTM5 MTARC1	38 interacting genes: AIG1 ANKRD13A ARLN CLDN19 CYB5R3 DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 GYPA HERC1 HEY1 HEYL HMOX2 HUWE1 INSIG2 ITCH KIR3DL3 KRT7 LDLRAD1 MRPL18 NEDD4L RNF168 RPRM RTP2 SLC22A2 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC UBE2J1 USP13 VAMP1 WWP1
Entrez ID		84976	7805
HPRD ID		06326	03280
Ensembl ID		ENSG00000154309	ENSG00000162511
Uniprot IDs		Q96F81	Q13571 Q5TBB8
PDB IDs		6XE6 7E2G 7E2H 7E2I
Enriched GO Terms of Interacting Partners?		Induction Of Programmed Cell Death Negative Regulation Of Pre-B Cell Receptor Expression Negative Regulation Of Autophagic Cell Death Positive Regulation Of Lysosomal Membrane Permeability Regulation Of Lysosomal Membrane Permeability Nitric-oxide Synthase Complex Nitrate Reductase Activity Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Nitrate Metabolic Process Molybdenum Ion Binding Nitrite Reductase Activity Molybdopterin Cofactor Binding Nitrite Reductase (NO-forming) Activity Positive Regulation Of Receptor Catabolic Process Defense Response To Tumor Cell Golgi To Lysosome Transport Negative Regulation Of Activated T Cell Proliferation Lysosomal Membrane Organization Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Vacuole Transport Nitric Oxide Biosynthetic Process Positive Regulation Of Macrophage Cytokine Production Negative Regulation Of Interleukin-2 Production Protein Targeting To Lysosome Negative Regulation Of T Cell Receptor Signaling Pathway Nitric Oxide Metabolic Process Positive Regulation Of Membrane Permeability Reactive Nitrogen Species Metabolic Process Negative Regulation Of B Cell Activation Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Activated T Cell Proliferation Regulation Of Macrophage Cytokine Production Positive Regulation Of Interleukin-12 Production Negative Regulation Of Type II Interferon Production Protein Sequestering Activity Protein Targeting To Vacuole Regulation Of T Cell Receptor Signaling Pathway Pyridoxal Phosphate Binding Protein Localization To Lysosome Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Establishment Of Protein Localization To Vacuole Regulation Of Interleukin-2 Production Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Interleukin-12 Production Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Membrane Permeability Negative Regulation Of T Cell Proliferation	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Clathrin Vesicle Coat Clathrin Binding Ubiquitin Binding Ubiquitin Ligase Complex Protein Modification Process Proteolysis Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Histone Ubiquitin Ligase Activity Modification-dependent Protein Catabolic Process Protein Polyubiquitination Protein Metabolic Process Protein K48-linked Ubiquitination Symbiont Entry Into Host Cell Catabolic Process Endosome Protein Monoubiquitination Macromolecule Catabolic Process Import Into Cell Endocytosis Biological Process Involved In Interaction With Host Plasma Membrane Protein Tag Activity Receptor Internalization Clathrin-coated Pit Ubiquitin-ubiquitin Ligase Activity Proteasomal Protein Catabolic Process Pulmonary Valve Morphogenesis Clathrin-coated Vesicle Tolerance Induction Proteasome Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Branched Polyubiquitination Endocardial Cushion Morphogenesis Circulatory System Development Mitochondrial Outer Membrane Membrane Extracellular Exosome Positive Regulation Of Protein Catabolic Process Negative Regulation Of Sprouting Angiogenesis Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein K63-linked Deubiquitination K63-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin-like Protein Ligase Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
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