PTPN5 and VTI1B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PTPN5	VTI1B
Description		protein tyrosine phosphatase non-receptor type 5	vesicle transport through interaction with t-SNAREs 1B
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Cell Junction	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Platelet Alpha Granule Lumen SNARE Complex Early Endosome Membrane Late Endosome Membrane Vesicle Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Presynaptic Endosome Membrane
	Molecular Function	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity
	Biological Process	Protein Dephosphorylation Signal Transduction	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Vesicle Docking Involved In Exocytosis Protein Transport Vesicle-mediated Transport Macroautophagy Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Membrane Fusion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane
Pathways		Interleukin-37 signaling	Platelet degranulation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Myopia ( 27182965) Refractive error ( 32231278)	Blood protein levels ( 30072576)
Interacting Genes		22 interacting genes: CCNQ CLEC4G CUL5 CXCL9 CYB561D2 ENTPD3 FCER1G FYN MAPK1 MAPK3 MARCHF5 MOB1A PLS3 PRKN SAAL1 SLC35B1 SNX4 TERF1 TMEM201 TMEM51 VTI1B ZBTB5	38 interacting genes: AQP6 ASGR2 BIK CD46 CD79A CFTR CRB3 CREB3 ERGIC3 FCGR1A GOLGB1 GPR35 GPX8 JAGN1 KASH5 KLRC1 KRTAP10-7 LDLRAD1 LMNA MANBAL PTPN5 REEP4 RNASEK SAR1A SLC16A7 SLC18A1 SLC35H1 STX1A STX2 STX4 STX7 STX8 SYNE4 TMEM14B TMEM234 TMEM51 TNK2 TRIM59
Entrez ID		84867	10490
HPRD ID		01472	04440
Ensembl ID		ENSG00000110786	ENSG00000100568
Uniprot IDs		B7Z2F8 P54829 Q86TL3	Q9UEU0
PDB IDs		2BIJ 2BV5 2CJZ 5OVR 5OVX 5OW1 6H8R 8SLS 8SLT 8SLU 9EEX 9EEY 9EEZ	2V8S
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Positive Regulation Of Defense Response ERBB2 Signaling Pathway Interleukin-34-mediated Signaling Pathway Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Organelle Organization Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Defense Response Negative Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Cellular Response To L-glutamate Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Inflammatory Response Immune Response-activating Signaling Pathway Bergmann Glial Cell Differentiation Reelin-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Immune Response ERBB Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Mast Cell Degranulation Activation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Protein K27-linked Ubiquitination Regulation Of Golgi Organization MAP Kinase Activity Pseudopodium Organelle Localization Layer Formation In Cerebral Cortex Response To L-glutamate Positive Regulation Of Macroautophagy Schwann Cell Development Regulation Of Early Endosome To Late Endosome Transport Phospholipase Binding Positive Regulation Of Mitochondrial Fission Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Chromosome Organization Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Protein K48-linked Ubiquitination Face Development Regulation Of Telomere Maintenance	Membrane Chloride Channel Inhibitor Activity Vesicle Docking Organelle Localization By Membrane Tethering SNAP Receptor Activity Membrane Docking SNARE Complex SNARE Binding Vesicle-mediated Transport Endomembrane System Vesicle Fusion Organelle Membrane Fusion Organelle Localization Membrane Organization Organelle Fusion Membrane Fusion Vesicle Organization Cornified Envelope Assembly Intracellular Protein Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Membrane Assembly Positive Regulation Of Immune Effector Process SNARE Complex Assembly Endoplasmic Reticulum Membrane Regulation Of Insulin Secretion Regulation Of Protein Localization Regulation Of Peptide Hormone Secretion Regulation Of Cellular Localization Positive Regulation Of Exocytosis Exocytosis Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Nuclear Envelope Organization Protein Binding Water Transport Endoplasmic Reticulum Regulation Of Adaptive Immune Response Neurotransmitter Transport Schaffer Collateral - CA1 Synapse Establishment Of Localization In Cell Nitrate Transmembrane Transporter Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Basolateral Plasma Membrane Protein Transport Presynaptic Active Zone Membrane High-affinity IgG Receptor Activity Inhibitory MHC Class Ib Receptor Activity
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