GPR65 and CKB

		GPR65	CKB
Description		G protein-coupled receptor 65	creatine kinase B
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GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Early Endosome Membrane Late Endosome Membrane	Extracellular Space Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity	Nucleotide Binding Catalytic Activity Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Ubiquitin Protein Ligase Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Acidic PH Positive Regulation Of Interleukin-22 Production Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Stress Fiber Assembly Cellular Response To Acidic PH	Substantia Nigra Development Phosphocreatine Biosynthetic Process Futile Creatine Cycle
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events	Creatine metabolism RND3 GTPase cycle
Drugs			Creatine Phosphocreatine
Diseases
GWAS		Ankylosing spondylitis ( 23749187) California verbal learning test score ( 31596458) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Crohn's disease ( 21102463 28067908) Degraded stimulus continuous performance test score ( 31596458) Diastolic blood pressure night-to-day ratio in hypertension ( 29973135) Eosinophil percentage of white cells ( 32888494) Food antigen IgG levels ( 24962563) Inflammatory bowel disease ( 23128233 28067908) Multiple sclerosis ( 21833088) Parkinson's disease ( 32201043) Takayasu arteritis ( 25604533)	Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Extremely high intelligence ( 29520040) Height ( 28552196 31562340) Schizophrenia ( 25056061)
Interacting Genes		2 interacting genes: CKB TRIP11	29 interacting genes: ACD ARIH2 ASB9 CKM CUL5 DIO3 DNAH5 EML1 ERBB2 EVL FUT8 GOLGA2 GPR65 IFI27 ILK JAG2 MLH1 OGT POT1 PPP1CA PSEN1 SERP2 SMG5 SNCA TAB1 TERF1 TINF2 TRIM63 UBE3A
Entrez ID		8477	1152
HPRD ID		07057	00423
Ensembl ID		ENSG00000140030	ENSG00000166165
Uniprot IDs		B5B0C2 Q8IYL9	A0A0S2Z471 P12277 V9HWH2
PDB IDs		9BHL	3B6R 3DRB 3DRE 6V9H 7BF1 7TUN
Enriched GO Terms of Interacting Partners?		Futile Creatine Cycle Phosphocreatine Biosynthetic Process Creatine Kinase Activity Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Vesicle Tethering To Golgi Golgi Ribbon Formation Transferase Activity, Transferring Phosphorus-containing Groups Acrosomal Membrane Vesicle Tethering Ventricular Septum Development Inner Ear Receptor Cell Stereocilium Organization Substantia Nigra Development Cardiac Septum Development Cis-Golgi Network Neural Nucleus Development Chondrocyte Differentiation	Shelterin Complex Telomeric DNA Binding Nuclear Telomere Cap Complex Telomere Capping Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Cellular Component Organization Cul5-RING Ubiquitin Ligase Complex Telomere Organization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Catabolic Process Protein Modification Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Chromosome, Telomeric Region Regulation Of Protein Localization Positive Regulation Of Organelle Organization Telomere Maintenance Via Telomere Lengthening Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Protein K48-linked Ubiquitination Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Regulation Of Cellular Component Organization Organelle Organization Intracellular Signal Transduction Protein Glycosylation Macromolecule Glycosylation Positive Regulation Of DNA Metabolic Process
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