SPSB2 and NRF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SPSB2	NRF1
Description		splA/ryanodine receptor domain and SOCS box containing 2	nuclear respiratory factor 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS		Colorectal cancer ( 26965516) Refractive error ( 32231278)	Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)
Interacting Genes		11 interacting genes: APP DDX4 FNDC3B GALNT15 NOS2 NRF1 PRMT1 RECK SMARCD1 TRIM55 TRIM63	48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC67A1-AS SP2 SP4 SPMIP10 SPSB2 SRARP TESMIN TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6
Entrez ID		84727	4899
HPRD ID		13610	02930
Ensembl ID		ENSG00000111671	ENSG00000106459
Uniprot IDs		Q99619	Q16656
PDB IDs		3EMW 5XN3 6DN5 6DN6 6JKJ 6JWM 6JWN 6KEY	8K3D 8K4L
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex PTB Domain Binding Response To Interleukin-1 Innate Immune Response Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cellular Response To Oxygen-containing Compound Chromatin Organization Epigenetic Regulation Of Gene Expression Defense Response To Symbiont Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Defense Response To Other Organism Positive Regulation Of Interleukin-6 Production Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Double-strand Break Repair GATOR1 Complex Binding Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Regulation Of Establishment Of Blood-brain Barrier Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Peptidase Inhibitor Activity Growth Factor Receptor Binding	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Medial Motor Column Neuron Differentiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Chromatin Zinc Ion Binding Regulation Of Primary Metabolic Process Motor Neuron Axon Guidance Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Spinal Cord Association Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm
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