SPMIP6 and PIGO

		SPMIP6	PIGO
Description		sperm microtubule inner protein 6	phosphatidylinositol glycan anchor biosynthesis class O
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Manchette Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Cilium Motile Cilium Sperm Flagellum Cell Projection Perinuclear Region Of Cytoplasm Sperm Midpiece Axonemal A Tubule Inner Sheath	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Alpha-tubulin Binding	Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Phosphotransferase Activity, For Other Substituted Phosphate Groups Mannose-ethanolamine Phosphotransferase Activity
	Biological Process	Spermatogenesis Cell Differentiation Flagellated Sperm Motility Protein-containing Complex Assembly	GPI Anchor Biosynthetic Process
Pathways			Synthesis of glycosylphosphatidylinositol (GPI)
Drugs
Diseases
GWAS			Response to quetiapine in schizophrenia ( 29503163) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		28 interacting genes: A1CF AIRIM BCAS2 BCL6 CABP2 CATSPER1 CCDC57 CDR2L CLIC3 COL8A1 CYSRT1 HGS HSF2BP KCTD9 KRTAP19-5 KRTAP19-6 KRTAP9-3 MEIS2 NOXA1 PIGO PIK3R3 PROP1 RBPMS SHBG SPG21 TEKT4 TSSK3 UBASH3A	6 interacting genes: APP COL15A1 MAP7 PHKA1 PIGF SPMIP6
Entrez ID		84688	84720
HPRD ID		12949	15134
Ensembl ID		ENSG00000164972	ENSG00000165282
Uniprot IDs		A0A8I5KRB0 Q8NCR6	Q8TEQ8
PDB IDs
Enriched GO Terms of Interacting Partners?			Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Perinuclear Region Of Cytoplasm Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Low-density Lipoprotein Particle Mediated Signaling Collagen Type XV Trimer Phosphorylase Kinase Complex Phosphorylase Kinase Activity Positive Regulation Of Glycogen Catabolic Process Ethanolaminephosphotransferase Activity Microtubule-based Process Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Regulation Of Glycogen Catabolic Process Peptidase Activator Activity Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen
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