USP32 and TRIM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		USP32	TRIM3
Description		ubiquitin specific peptidase 32	tripartite motif containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Endomembrane System Membrane	Cytoplasm Endosome Early Endosome Golgi Apparatus Dendrite Cell Projection
	Molecular Function	Cysteine-type Deubiquitinase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Proteolysis Protein Deubiquitination Positive Regulation Of TORC1 Signaling	Protein Polyubiquitination Toll-like Receptor Signaling Pathway Nervous System Development Protein Transport Protein Ubiquitination Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Interleukin-6 levels ( 33517400)	Malaria ( 31844061)
Interacting Genes		13 interacting genes: ANKRD29 DYRK1A MEOX2 MTNR1A NCK2 RAB35 RBCK1 RNF144A TRIM3 TRIM46 TRIM74 UBC ZDHHC17	34 interacting genes: ACTN4 ASL CDKN1A CEP70 CSNK1D CSNK1E DNMT1 FXR1 FXR2 KCTD7 KIF21B LNX1 LRRC8E MYO5A MYO5B ROPN1 TEAD1 TEAD2 TNFAIP3 TPTEP2-CSNK1E TRIM21 TSC1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2G2 UBE2K UBE2U UBE2W UBE2Z USP32
Entrez ID		84669	10612
HPRD ID		07612	05690
Ensembl ID		ENSG00000170832	ENSG00000110171
Uniprot IDs		Q8NFA0	B7Z5Y8 O75382
PDB IDs			7O0B 7QRW 8AMR
Enriched GO Terms of Interacting Partners?		Protein Modification Process Histone H3T45 Kinase Activity Endosome Membrane Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Immune System Process Ubiquitin Protein Ligase Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Anterograde Dense Core Granule Transport	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process ATP Binding Proteolysis Involved In Protein Catabolic Process Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Nucleotide Binding Protein Monoubiquitination Macromolecule Catabolic Process Protein K11-linked Ubiquitination Protein Metabolic Process TEAD-YAP Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Protein K6-linked Ubiquitination ISG15 Transferase Activity Regulation Of TORC1 Signaling Vesicle Transport Along Actin Filament ISG15-protein Conjugation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Catabolic Process Regulation Of TOR Signaling Cytosol TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process Protein Autoubiquitination Positive Regulation Of Non-canonical Wnt Signaling Pathway Protein K63-linked Ubiquitination Filopodium Tip Protein K27-linked Ubiquitination Translation Regulator Activity Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity TOR Signaling Positive Regulation Of Catabolic Process Negative Regulation Of TOR Signaling Cytoplasmic Stress Granule Nucleus Regulation Of Non-canonical Wnt Signaling Pathway Cellular Response To Interferon-beta
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