SLC71A2 and FMO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC71A2	FMO1
Description		solute carrier family 71 member 2	flavin containing dimethylaniline monoxygenase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Transmembrane Transporter Activity	Monooxygenase Activity N,N-dimethylaniline Monooxygenase Activity Protein Binding Oxidoreductase Activity Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Transmembrane Transport	Sulfur Amino Acid Catabolic Process Organic Acid Metabolic Process Xenobiotic Metabolic Process Toxin Metabolic Process Response To Lipopolysaccharide Taurine Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Energy Homeostasis
Pathways			Degradation of cysteine and homocysteine FMO oxidises nucleophiles
Drugs
Diseases
GWAS			Metabolite levels ( 23823483) Sudden cardiac arrest ( 21658281) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		76 interacting genes: ADIPOQ AGPAT3 AGPAT4 ARL6IP1 ARLN ATP13A1 BNIP3 C14orf180 CCL4L2 CFHR5 CLDN4 CMTM3 COMT CSGALNACT2 CTSA CYB5B CYBC1 DEFB127 DNAJC30 EMC6 ERG28 ETS2 FKBP8 FMO1 FUNDC2 GIMAP1 GOSR2 GRM2 KTN1 LAT LEPROTL1 LPCAT2 LRP10 MGLL MS4A1 NAT8 ORMDL1 PEX16 PKMYT1 PRRT2 RNF24 SACM1L SCD SERP1 SERP2 SLC25A46 SLC39A9 SLC66A2 SMAGP STX3 TECR THSD7B TIMMDC1 TMBIM6 TMEM119 TMEM167B TMEM176A TMEM19 TMEM208 TMEM229B TMEM239 TMEM31 TMX2 TPRG1 TRARG1 TREX1 TSNARE1 UBE2J1 UNC50 USE1 YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC24 ZFPL1	8 interacting genes: CREB3 FLT3 GRINA LEPROTL1 REEP4 SLC10A6 SLC71A2 TLN1
Entrez ID		84641	2326
HPRD ID		07869	00631
Ensembl ID		ENSG00000148110	ENSG00000010932
Uniprot IDs		Q5SR56	B2RCG5 Q01740
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Endomembrane System Membrane Organization Organelle Membrane Fusion Vesicle Fusion Membrane Fusion Golgi Trans Cisterna Golgi Medial Cisterna Vesicle-mediated Transport Lysophosphatidic Acid Acyltransferase Activity Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane SNAP Receptor Activity Organelle Fusion SNARE Complex Golgi Apparatus 1-acylglycerol-3-phosphate O-acyltransferase Activity Cellular Localization Golgi Membrane Trans-Golgi Network Establishment Of Protein Localization To Membrane Secretion By Cell Protein Binding Establishment Of Protein Localization Lipid Biosynthetic Process Acyltransferase Activity	Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Deacetylase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Membrane Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
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