PARD6B and PARD3

Number of citations of the paper that reports this interaction (PubMedID 14676191)
0

Data Source:
HPRD (in vitro)

		PARD6B	PARD3
Description		par-6 family cell polarity regulator beta	par-3 family cell polarity regulator
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Apical Part Of Cell Extracellular Exosome Tight Junction Anchoring Junction PAR Polarity Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Membrane Apical Plasma Membrane Cell Junction Internode Region Of Axon Apical Junction Complex Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Cell-cell Junction Assembly Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Axonogenesis Regulation Of Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Regulation Of Cellular Localization Protein-containing Complex Assembly	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Adhesion Establishment Or Maintenance Of Cell Polarity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Intracellular Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Cell Differentiation Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Establishment Of Centrosome Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity
Pathways		Tight junction interactions RHOV GTPase cycle	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS		Bipolar disorder ( 21771265)	Acute lymphoblastic leukemia (childhood) ( 19684603) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Parkinson's disease progression (composite) ( 33111402) Schizophrenia ( 21682944)
Interacting Genes		34 interacting genes: APP ARAP3 BANP CDC42 CDCA4 CEP76 FRMD6 GMCL1 GOLGA2 HSF2BP HTRA1 MAGOHB OGT PALS1 PARD3 PARD3B PARD6A PNMA1 PRKCG PRKCI PRKCZ RAC1 RASSF3 RHOJ RHOQ SIAH1 TCP10L3 TRIB3 TRIM35 WDR83 YWHAB YWHAH YWHAZ ZSCAN4	34 interacting genes: ACE2 AP1B1 CDC42 DYNLL1 F11R HNF1B INSC LIMK2 MAP3K8 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 TTN UBC YWHAB YWHAG YWHAH YWHAZ
Entrez ID		84612	56288
HPRD ID		18703	05994
Ensembl ID		ENSG00000124171	ENSG00000148498
Uniprot IDs		Q9BYG5	Q8TEW0
PDB IDs			2KOM
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity PAR Polarity Complex Establishment Of Cell Polarity Bicellular Tight Junction Apical Junction Complex Tight Junction GBD Domain Binding Cytoplasm Diacylglycerol-dependent Serine/threonine Kinase Activity GTP-dependent Protein Binding Cytoskeleton Organization Intracellular Protein Localization Response To Insulin Cell-cell Junction Organization Protein Kinase Binding Cell Cortex Response To Peptide Hormone Supramolecular Fiber Organization Cellular Response To Insulin Stimulus Regulation Of Synaptic Plasticity Phosphoserine Residue Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Apical Plasma Membrane G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Identical Protein Binding Intracellular Signal Transduction Establishment Of Golgi Localization Negative Regulation Of Protein Localization To Nucleus Actin Filament Organization Thioesterase Binding Establishment Of Centrosome Localization Organelle Organization Schmidt-Lanterman Incisure Plasma Membrane Cell Junction Organization Asymmetric Cell Division Regulation Of Synapse Organization Regulation Of Protein Localization Golgi Localization Regulation Of Cell Communication Extracellular Exosome Regulation Of Signaling Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Cellular Response To Peptide Hormone Stimulus Regulation Of Insulin Receptor Signaling Pathway Regulation Of D-glucose Transmembrane Transport Cellular Localization	Heteromeric SMAD Protein Complex Intracellular Signal Transduction I-SMAD Binding Tight Junction PAR Polarity Complex Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity SMAD Protein Complex Establishment Or Maintenance Of Apical/basal Cell Polarity SMAD Protein Signal Transduction Cell-cell Junction Organization Cytosol Protein-containing Complex Establishment Or Maintenance Of Cell Polarity Mesonephric Tubule Development Mesonephric Epithelium Development Identical Protein Binding Cytoplasm Regulation Of Cellular Component Organization Bicellular Tight Junction Tube Development Kidney Epithelium Development Positive Regulation Of Cell Differentiation Endoderm Development Regulation Of Protein Localization Anchoring Junction Ureteric Bud Development Co-SMAD Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Localization Primary MiRNA Processing Golgi Localization Cell Junction Organization Intracellular Protein Localization Extracellular Exosome Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Transport Homomeric SMAD Protein Complex Cardiac Conduction System Development Regulation Of Cell Differentiation Intracellular Signaling Cassette Regulation Of Signaling Regulation Of Cell Communication Regulation Of Transport Signal Transduction Embryonic Pattern Specification Epithelium Development Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Localization Transcription Regulator Complex Response To Monosaccharide
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