CUL1 and NLRP3

Number of citations of the paper that reports this interaction (PubMedID 30653357)
0

Data Source:
BioGRID (protein complementation assay)

		CUL1	NLRP3
Description		cullin 1	NLR family pyrin domain containing 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Golgi Membrane Extracellular Region Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Membrane Interphase Microtubule Organizing Center Canonical Inflammasome Complex NLRP3 Inflammasome Complex
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding Peptidoglycan Binding ADP Binding Sequence-specific DNA Binding Molecular Adaptor Activity Phosphatidylinositol-4-phosphate Binding DNA-binding Transcription Factor Binding Molecular Sensor Activity Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity Phosphatidylinositol Phosphate Binding
	Biological Process	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Lysosome Organization Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Oxidative Stress TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling	Pattern Recognition Receptor Signaling Pathway Immune System Process Negative Regulation Of Acute Inflammatory Response Positive Regulation Of Type 2 Immune Response Regulation Of DNA-templated Transcription Apoptotic Process Defense Response Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Detection Of Biotic Stimulus Response To Virus Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-4 Production Interleukin-18-mediated Signaling Pathway NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Protein Maturation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Virus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins	Metalloprotease DUBs The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Cytoprotection by HMOX1
Drugs
Diseases			Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Uterine fibroid size (maximum volume) ( 30196971)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) C-reactive protein levels ( 21300955 30388399) Fibrinogen ( 23969696 20031576) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252 32888494) Word reading ( 23738518)
Interacting Genes		62 interacting genes: BTRC CAND1 CDC34 CDCA3 CDK9 CEBPA CENPE CENPW CFLAR CFTR CHEK1 CHUK CKS1B COMMD1 COPS5 COPS6 COPS8 DLEU2 DVL2 E2F1 EIF4ENIF1 FBH1 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 FBXW8 GHR GPS1 HIPK2 HOOK1 KHNYN NEDD8 NFKBIA NFKBIB NFKBIE NLK NLRP3 NR1D2 PPP1CA PRKN PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBC UBE2E3 UBE2F UBE2M ZC3HC1	15 interacting genes: ANAPC10 ATP1B3 CARD8 CD82 CSNK1A1 CUL1 FAF1 FBXL2 HERC5 IRGM LAMTOR1 MARCHF7 MARK4 PGM1 PYCARD
Entrez ID		8454	114548
HPRD ID		04389	05915
Ensembl ID		ENSG00000055130	ENSG00000162711
Uniprot IDs		A0A090N7U0 B3KTW0 Q13616	A0A7I2PJH0 A0A7I2PMC6 A0A7I2PRX0 A0A7I2R3P8 Q96P20
PDB IDs		1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52 4P5O 5V89 6TTU 6WCQ 7B5L 7B5M 7B5N 7B5R 7B5S 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8CAF 8CDJ 8CDK 8OR0 8OR2 8OR3 8OR4 8UA6 8UBT 8UBU 8VVY 9JKB 9KBD	2NAQ 3QF2 6NPY 7ALV 7PZC 7PZD 7VTP 7ZGU 8EJ4 8ERT 8ETR 8RI2 8SWF 8SWK 8SXN 8WSM 8ZEM 9DH3 9GU4 9MGY 9MIE 9MIG
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation SCF Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification Process Protein Metabolic Process Protein Neddylation Macromolecule Metabolic Process Cytosol Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Nucleus Nucleoplasm Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Deneddylation Macromolecule Catabolic Process NEDD8 Transferase Activity Protein K48-linked Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein Polyubiquitination Cytoplasm Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Intracellular Signal Transduction Cul7-RING Ubiquitin Ligase Complex NEDD8 Ligase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Protein Monoubiquitination Ubiquitin-like Ligase-substrate Adaptor Activity Cullin Family Protein Binding Positive Regulation Of Signal Transduction Protein Destabilization Intracellular Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of NLRP3 Inflammasome Complex Assembly Canonical Inflammasome Complex Assembly Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Autophagy NLRP3 Inflammasome Complex Assembly Regulation Of Protein-containing Complex Assembly Autophagosome Assembly Autophagosome Organization Negative Regulation Of Intracellular Signal Transduction Protein Metabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Protein Catabolic Process Regulation Of Intracellular Signal Transduction Vacuole Organization Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Response To Virus SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process TORC1 Signaling Lysosome Organization NLRP3 Inflammasome Complex Regulation Of Defense Response To Virus Proteolysis Cysteine-type Endopeptidase Activator Activity Proteasomal Protein Catabolic Process Intracellular Signal Transduction Post-translational Protein Modification TOR Signaling Canonical Inflammasome Complex CARD Domain Binding Catabolic Process Regulation Of TORC1 Signaling Negative Regulation Of Signal Transduction Defense Response To Virus Ubiquitin Binding Negative Regulation Of Autophagy Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity Innate Immune Response Protein Modification By Small Protein Conjugation
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