CUL4B and ST7

Number of citations of the paper that reports this interaction (PubMedID 30945288)
0

Data Source:
BioGRID (enzymatic study)

		CUL4B	ST7
Description		cullin 4B	suppression of tumorigenicity 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Membrane
	Molecular Function	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Gene Expression Proteasomal Protein Catabolic Process Protein Ubiquitination Cellular Response To UV Ribosome Biogenesis Positive Regulation Of Protein Catabolic Process Astrocyte Differentiation UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Extracellular Matrix Organization Regulation Of Cell Differentiation
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 30591961) Response to alcohol consumption (flushing response) ( 29460428) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		47 interacting genes: AHR APP AR BRWD1 BRWD3 CAND1 CDK1 COMMD1 COP1 COPS5 CSNK1A1 DCAF10 DCAF11 DCAF12 DCAF16 DCAF17 DCAF5 DCUN1D4 DDA1 DDB1 DDB2 DNMT3B ESR1 HDAC2 HDAC3 HUWE1 KPNA2 KPNA4 KPNB1 MTA2 NEDD8 PAFAH1B1 PLK1 PLS3 PRDX3 PTEN PWP1 RBX1 SALL2 SIN3A SIRT1 SRC ST7 TBL3 UBC UBE2D3 ZMAT4	9 interacting genes: ACTN2 CUL4A CUL4B DCAF4 MYOT NFKBIA RACK1 SNAPIN ZFYVE9
Entrez ID		8450	7982
HPRD ID		02251	09015
Ensembl ID		ENSG00000158290	ENSG00000004866
Uniprot IDs		K4DI93 Q13620	B7Z4L1 B7Z4U3 E7EPD9 E7EPW5 G3XAH9 H7BXS2 Q9NRC1 X5DRA0
PDB IDs		2DO7 4A0C 4A0L 4A64 8EI1
Enriched GO Terms of Interacting Partners?		Cul4-RING E3 Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein Ubiquitination Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Protein Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Positive Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Enzyme Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Histone Deacetylase Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Response To Hydrogen Peroxide Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Cul4B-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Response To Oxidative Stress Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex	Cul4-RING E3 Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Regulation Of Cellular Localization Positive Regulation Of Protein Catabolic Process Protein Ubiquitination Structural Constituent Of Muscle Regulation Of Intracellular Transport Protein Modification By Small Protein Conjugation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Actin Filament Uncapping Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Late Endosome To Lysosome Transport Post-translational Protein Modification Titin Z Domain Binding Negative Regulation Of Transport Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To UV Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Phospholipase C-activating Angiotensin-activated Signaling Pathway I-kappaB/NF-kappaB Complex Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Light Stimulus Ribosome Biogenesis Positive Regulation Of Mitotic Cell Cycle Microspike Assembly Z Disc Positive Regulation Of Intracellular Transport FATZ Binding Regulation Of Vesicle-mediated Transport Mitotic Cell Cycle Phase Transition Positive Regulation Of Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal Negative Regulation Of Translational Elongation Terminal Button Organization Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Response To UV Cell Cycle Phase Transition Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Golgi To Plasma Membrane Protein Transport BH3 Domain Binding
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