LCOR and ENPP2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		LCOR	ENPP2
Description		ligand dependent nuclear receptor corepressor	ectonucleotide pyrophosphatase/phosphodiesterase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Region Extracellular Space Plasma Membrane
	Molecular Function	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding	Nucleic Acid Binding Phosphodiesterase I Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase D Activity Scavenger Receptor Activity Calcium Ion Binding Zinc Ion Binding Hydrolase Activity Polysaccharide Binding Metal Ion Binding Alkylglycerophosphoethanolamine Phosphodiesterase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Lipid Metabolic Process Phospholipid Metabolic Process Chemotaxis Immune Response Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Lipid Catabolic Process Vesicle-mediated Transport Sphingolipid Catabolic Process Regulation Of Cell Migration Phosphatidylcholine Catabolic Process Cell Motility Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lamellipodium Morphogenesis
Pathways			Vitamin B5 (pantothenate) metabolism
Drugs
Diseases
GWAS		Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cortical volume ( 32963231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595 28552196 31562340) Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693) Major depressive episode treated with electroconvulsive therapy ( 33483693) Offspring birth weight ( 31043758)
Interacting Genes		144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE	4 interacting genes: DYRK1A HSPB1 LCOR TOR1A
Entrez ID		84458	5168
HPRD ID		07609	03037
Ensembl ID		ENSG00000196233	ENSG00000136960
Uniprot IDs		Q96JN0	E7EUF1 Q13822
PDB IDs		2COB 6V3X 6V3Y	4ZG6 4ZG7 4ZG9 4ZGA 5KXA 5M7M 5MHP 8C3O 8C3P
Enriched GO Terms of Interacting Partners?		Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Cytoskeletal Protein Binding Histone H3T45 Kinase Activity Unfolded Protein Binding Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Regulation Of Heterochromatin Formation Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Folding Positive Regulation Of Synaptic Vesicle Recycling Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cytoskeleton Neurofilament Protein Deneddylation Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Synaptic Vesicle Membrane Organization Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Contractile Muscle Fiber Histone Methyltransferase Binding Identical Protein Binding Misfolded Protein Binding
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