GNPAT and RAB35

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		GNPAT	RAB35
Description		glyceronephosphate O-acyltransferase	RAB35, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane Cell Junction	Endosome Cytosol Plasma Membrane Clathrin-coated Pit Endosome Membrane Membrane Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Cell Projection Membrane Cytoplasmic Vesicle Melanosome Intercellular Bridge Clathrin-coated Endocytic Vesicle Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Catalytic Activity O-acyltransferase Activity Glycerone-phosphate O-acyltransferase Activity Transferase Activity Acyltransferase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Hydrolase Activity GDP Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Synapse Assembly Ether Lipid Biosynthetic Process Cerebellum Morphogenesis Paranodal Junction Assembly Myelination Membrane Organization	Mitotic Cytokinesis Intracellular Protein Localization Protein Transport Endosomal Transport Antigen Processing And Presentation Neuron Projection Development Endocytic Recycling Rab Protein Signal Transduction Protein Localization To Endosome Plasma Membrane To Endosome Transport Cellular Response To Nerve Growth Factor Stimulus
Pathways		Synthesis of PA Plasmalogen biosynthesis Peroxisomal protein import Peroxisomal protein import	TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)
GWAS			Heel bone mineral density ( 30598549)
Interacting Genes		6 interacting genes: AGPS GPR3 HSPB1 PEX5 RAB35 VDR	12 interacting genes: APP CALCOCO2 CBR3 DENND1B GNPAT IDH3B MPHOSPH9 PTPRS TBPL1 TRIM54 USP32 WDCP
Entrez ID		8443	11021
HPRD ID		04120	05010
Ensembl ID		ENSG00000116906	ENSG00000111737
Uniprot IDs		O15228	Q15286
PDB IDs			3TW8 6EKK 6IF2 6IF3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Inhibitor Activity Protein Import Into Peroxisome Matrix, Translocation Peroxisome Membrane Targeting Sequence Binding Peroxisome Peroxisome Matrix Targeting Signal-1 Binding Peroxisomal Matrix Peroxisome Targeting Sequence Binding Peroxisomal Membrane Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Phosphate Transmembrane Transport Calcitriol Binding Nuclear Receptor-mediated Bile Acid Signaling Pathway Apoptotic Process Involved In Mammary Gland Involution Vitamin D Response Element Binding Bile Acid Nuclear Receptor Activity Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Lithocholic Acid Binding Alkylglycerone-phosphate Synthase Activity Regulation Of Protein Kinase C Signaling Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Vitamin D Binding Positive Regulation Of Apoptotic Process Involved In Morphogenesis Sphingosine-1-phosphate Receptor Activity Anterograde Axonal Protein Transport Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Vitamin D Receptor Signaling Pathway Regulation Of Phosphate Transport Plasma Membrane To Endosome Transport Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Protein Transport Along Microtubule Response To Growth Factor Contractile Muscle Fiber Protein Unfolding Protein Import Into Peroxisome Matrix Phosphate Ion Transmembrane Transport Ether Lipid Biosynthetic Process Protein Localization To Endosome Cell Projection Membrane
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