NIFK and MKI67

Number of citations of the paper that reports this interaction (PubMedID 11342549)
0

Data Source:
HPRD (two hybrid, in vitro)

		NIFK	MKI67
Description		nucleolar protein interacting with the FHA domain of MKI67	marker of proliferation Ki-67
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm	Condensed Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Nucleotide Binding DNA Binding RNA Binding Protein Binding ATP Binding Molecular Condensate Scaffold Activity
	Biological Process	RRNA Transcription RRNA Metabolic Process Protein-containing Complex Assembly	Chromosome Segregation Regulation Of Mitotic Nuclear Division Cell Population Proliferation Regulation Of Chromatin Organization
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease in APOE e4- carriers ( 25778476) Drug experimentation measurement ( 30718321) Lead levels ( 26025379) Select biomarker traits ( 17903293) Suicide attempt severity in mood disorders ( 33783297) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		5 interacting genes: CEBPA MKI67 SAP130 TNIP1 ZDHHC17	19 interacting genes: CBX3 CBX5 CDC20 CDH1 CDK1 CEBPA DRD4 ECPAS HINFP KIF15 NIFK PPP1CA PRKCB PTEN SMN1 SUMO2 TK1 TRIM55 TRIM63
Entrez ID		84365	4288
HPRD ID		17576	08902
Ensembl ID		ENSG00000155438	ENSG00000148773
Uniprot IDs		Q9BYG3	P46013
PDB IDs		2AFF 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL3 8FL6 8FL7 8FLA 8FLB 8FLD 8FLE 8INE 8INF 8IPX 8IPY 8IR3	1R21 2AFF 5J28
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse CHOP-C/EBP Complex White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Inflammatory Response Rb-E2F Complex Positive Regulation Of Protein Deubiquitination Protein-cysteine S-myristoyltransferase Activity	DNA Synthesis Involved In Mitotic DNA Replication Chromatin Binding Rhythmic Process Thymidine Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Thymidine Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleoplasm Negative Regulation Of Cell Cycle Chromosome, Telomeric Region Regulation Of Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex Binding Identical Protein Binding Macromolecule Metabolic Process Mitotic Nuclear Membrane Disassembly Positive Regulation Of Proteolysis Ubiquitin Ligase Activator Activity Pyrimidine Nucleoside Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Postsynapse Spindle Nuclear Membrane Disassembly Cellular Response To Lithium Ion Response To Stress Membrane Disassembly Spindle Assembly Response To Lithium Ion Protein Modification Process Negative Regulation Of Cell Cycle Process PML Body Nucleus Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Histone Deacetylase Binding Regulation Of Generation Of Precursor Metabolites And Energy Response To Glucocorticoid Response To Metal Ion Presynaptic Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly Pericentric Heterochromatin Mitotic Cell Cycle Phase Transition Centrosome Macromolecule Biosynthetic Process Response To Corticosteroid Regulation Of Nucleobase-containing Compound Metabolic Process
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